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Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn’s disease. Impor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796135/ https://www.ncbi.nlm.nih.gov/pubmed/33374769 http://dx.doi.org/10.3390/molecules26010031 |
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author | Weinberg, Samuel E. Sun, Le Yu Yang, Allison L. Liao, Jie Yang, Guang Yu |
author_facet | Weinberg, Samuel E. Sun, Le Yu Yang, Allison L. Liao, Jie Yang, Guang Yu |
author_sort | Weinberg, Samuel E. |
collection | PubMed |
description | Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn’s disease. Importantly, patients with IBD have a significantly increased risk for the development of colorectal carcinoma. Dietary inositol and its phosphates, as well as phospholipid derivatives, are well known to benefit human health in diverse pathologies including cancer prevention. Inositol phosphates including InsP(3), InsP(6), and other pyrophosphates, play important roles in cellular metabolic and signal transduction pathways involved in the control of cell proliferation, differentiation, RNA export, DNA repair, energy transduction, ATP regeneration, and numerous others. In the review, we highlight the biologic function and health effects of inositol and its phosphates including the nature and sources of these molecules, potential nutritional deficiencies, their biologic metabolism and function, and finally, their role in the prevention of colitis-induced carcinogenesis. |
format | Online Article Text |
id | pubmed-7796135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77961352021-01-10 Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis Weinberg, Samuel E. Sun, Le Yu Yang, Allison L. Liao, Jie Yang, Guang Yu Molecules Review Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn’s disease. Importantly, patients with IBD have a significantly increased risk for the development of colorectal carcinoma. Dietary inositol and its phosphates, as well as phospholipid derivatives, are well known to benefit human health in diverse pathologies including cancer prevention. Inositol phosphates including InsP(3), InsP(6), and other pyrophosphates, play important roles in cellular metabolic and signal transduction pathways involved in the control of cell proliferation, differentiation, RNA export, DNA repair, energy transduction, ATP regeneration, and numerous others. In the review, we highlight the biologic function and health effects of inositol and its phosphates including the nature and sources of these molecules, potential nutritional deficiencies, their biologic metabolism and function, and finally, their role in the prevention of colitis-induced carcinogenesis. MDPI 2020-12-23 /pmc/articles/PMC7796135/ /pubmed/33374769 http://dx.doi.org/10.3390/molecules26010031 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Weinberg, Samuel E. Sun, Le Yu Yang, Allison L. Liao, Jie Yang, Guang Yu Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis |
title | Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis |
title_full | Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis |
title_fullStr | Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis |
title_full_unstemmed | Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis |
title_short | Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis |
title_sort | overview of inositol and inositol phosphates on chemoprevention of colitis-induced carcinogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796135/ https://www.ncbi.nlm.nih.gov/pubmed/33374769 http://dx.doi.org/10.3390/molecules26010031 |
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