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Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells

Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants produced by incomplete combustion of organic matter. They induce their own metabolism by upregulating xenobiotic-metabolizing enzymes such as cytochrome P450 monooxygenase 1A1 (CYP1A1) by activating the aryl hydrocarbon receptor (A...

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Detalles Bibliográficos
Autores principales:	Goedtke, Lisa, Sprenger, Heike, Hofmann, Ute, Schmidt, Felix F., Hammer, Helen S., Zanger, Ulrich M., Poetz, Oliver, Seidel, Albrecht, Braeuning, Albert, Hessel-Pras, Stefanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796163/ https://www.ncbi.nlm.nih.gov/pubmed/33396476 http://dx.doi.org/10.3390/ijms22010372

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