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Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”
The term “normobaric oxygen paradox” (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1α (HIF-1α) transcription factor activity. The molecular characteristics of this...
Autores principales: | Fratantonio, Deborah, Virgili, Fabio, Zucchi, Alessandro, Lambrechts, Kate, Latronico, Tiziana, Lafère, Pierre, Germonpré, Peter, Balestra, Costantino |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796168/ https://www.ncbi.nlm.nih.gov/pubmed/33466421 http://dx.doi.org/10.3390/ijms22010458 |
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