Cargando…
New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion
Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabete...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796187/ https://www.ncbi.nlm.nih.gov/pubmed/33396793 http://dx.doi.org/10.3390/molecules26010136 |
_version_ | 1783634622918164480 |
---|---|
author | Theysgeur, Sandy Cudennec, Benoit Deracinois, Barbara Perrin, Claire Guiller, Isabelle Lepoudère, Anne Flahaut, Christophe Ravallec, Rozenn |
author_facet | Theysgeur, Sandy Cudennec, Benoit Deracinois, Barbara Perrin, Claire Guiller, Isabelle Lepoudère, Anne Flahaut, Christophe Ravallec, Rozenn |
author_sort | Theysgeur, Sandy |
collection | PubMed |
description | Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer. |
format | Online Article Text |
id | pubmed-7796187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77961872021-01-10 New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion Theysgeur, Sandy Cudennec, Benoit Deracinois, Barbara Perrin, Claire Guiller, Isabelle Lepoudère, Anne Flahaut, Christophe Ravallec, Rozenn Molecules Article Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer. MDPI 2020-12-30 /pmc/articles/PMC7796187/ /pubmed/33396793 http://dx.doi.org/10.3390/molecules26010136 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Theysgeur, Sandy Cudennec, Benoit Deracinois, Barbara Perrin, Claire Guiller, Isabelle Lepoudère, Anne Flahaut, Christophe Ravallec, Rozenn New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion |
title | New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion |
title_full | New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion |
title_fullStr | New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion |
title_full_unstemmed | New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion |
title_short | New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion |
title_sort | new bioactive peptides identified from a tilapia byproduct hydrolysate exerting effects on dpp-iv activity and intestinal hormones regulation after canine gastrointestinal simulated digestion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796187/ https://www.ncbi.nlm.nih.gov/pubmed/33396793 http://dx.doi.org/10.3390/molecules26010136 |
work_keys_str_mv | AT theysgeursandy newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion AT cudennecbenoit newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion AT deracinoisbarbara newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion AT perrinclaire newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion AT guillerisabelle newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion AT lepoudereanne newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion AT flahautchristophe newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion AT ravallecrozenn newbioactivepeptidesidentifiedfromatilapiabyproducthydrolysateexertingeffectsondppivactivityandintestinalhormonesregulationaftercaninegastrointestinalsimulateddigestion |