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Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature
Endoscopic resection has been the standard treatment for intramucosal esophageal cancers (ECs) because of the low risk of lymph node metastases in the lesions. In recent years, endoscopic submucosal dissection (ESD), which can resect large ECs, has been performed. However, the risk of esophageal str...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796365/ https://www.ncbi.nlm.nih.gov/pubmed/33374780 http://dx.doi.org/10.3390/jcm10010020 |
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author | Hikichi, Takuto Nakamura, Jun Takasumi, Mika Hashimoto, Minami Kato, Tsunetaka Kobashi, Ryoichiro Takagi, Tadayuki Suzuki, Rei Sugimoto, Mitsuru Sato, Yuki Irie, Hiroki Okubo, Yoshinori Kobayakawa, Masao Ohira, Hiromasa |
author_facet | Hikichi, Takuto Nakamura, Jun Takasumi, Mika Hashimoto, Minami Kato, Tsunetaka Kobashi, Ryoichiro Takagi, Tadayuki Suzuki, Rei Sugimoto, Mitsuru Sato, Yuki Irie, Hiroki Okubo, Yoshinori Kobayakawa, Masao Ohira, Hiromasa |
author_sort | Hikichi, Takuto |
collection | PubMed |
description | Endoscopic resection has been the standard treatment for intramucosal esophageal cancers (ECs) because of the low risk of lymph node metastases in the lesions. In recent years, endoscopic submucosal dissection (ESD), which can resect large ECs, has been performed. However, the risk of esophageal stricture after ESD is high when the mucosal defect caused by the treatment exceeds 3/4 of the circumference of the lumen. Despite the subsequent high risk of luminal stricture, ESD has been performed even in cases of circumferential EC. In such cases, it is necessary to take measures to prevent stricture. Therefore, in this review, we aimed to clarify the current status of stricture prevention methods after esophageal ESD based on previous literature. Although various prophylactic methods have been reported to have stricture-preventing effects, steroid injection therapy and oral steroid administration are mainstream. However, in cases of circumferential EC, both steroid injection therapy and oral steroid administration cannot effectively prevent luminal stricture. To solve this issue, clinical applications, such as tissue shielding methods with polyglycolic acid sheet, autologous oral mucosal epithelial sheet transplantation, and stent placement, have been developed. However, effective prophylaxis of post-ESD mucosal defects of the esophagus is still unclear. Therefore, further studies in this research field are needed. |
format | Online Article Text |
id | pubmed-7796365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77963652021-01-10 Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature Hikichi, Takuto Nakamura, Jun Takasumi, Mika Hashimoto, Minami Kato, Tsunetaka Kobashi, Ryoichiro Takagi, Tadayuki Suzuki, Rei Sugimoto, Mitsuru Sato, Yuki Irie, Hiroki Okubo, Yoshinori Kobayakawa, Masao Ohira, Hiromasa J Clin Med Review Endoscopic resection has been the standard treatment for intramucosal esophageal cancers (ECs) because of the low risk of lymph node metastases in the lesions. In recent years, endoscopic submucosal dissection (ESD), which can resect large ECs, has been performed. However, the risk of esophageal stricture after ESD is high when the mucosal defect caused by the treatment exceeds 3/4 of the circumference of the lumen. Despite the subsequent high risk of luminal stricture, ESD has been performed even in cases of circumferential EC. In such cases, it is necessary to take measures to prevent stricture. Therefore, in this review, we aimed to clarify the current status of stricture prevention methods after esophageal ESD based on previous literature. Although various prophylactic methods have been reported to have stricture-preventing effects, steroid injection therapy and oral steroid administration are mainstream. However, in cases of circumferential EC, both steroid injection therapy and oral steroid administration cannot effectively prevent luminal stricture. To solve this issue, clinical applications, such as tissue shielding methods with polyglycolic acid sheet, autologous oral mucosal epithelial sheet transplantation, and stent placement, have been developed. However, effective prophylaxis of post-ESD mucosal defects of the esophagus is still unclear. Therefore, further studies in this research field are needed. MDPI 2020-12-23 /pmc/articles/PMC7796365/ /pubmed/33374780 http://dx.doi.org/10.3390/jcm10010020 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hikichi, Takuto Nakamura, Jun Takasumi, Mika Hashimoto, Minami Kato, Tsunetaka Kobashi, Ryoichiro Takagi, Tadayuki Suzuki, Rei Sugimoto, Mitsuru Sato, Yuki Irie, Hiroki Okubo, Yoshinori Kobayakawa, Masao Ohira, Hiromasa Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature |
title | Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature |
title_full | Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature |
title_fullStr | Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature |
title_full_unstemmed | Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature |
title_short | Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature |
title_sort | prevention of stricture after endoscopic submucosal dissection for superficial esophageal cancer: a review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796365/ https://www.ncbi.nlm.nih.gov/pubmed/33374780 http://dx.doi.org/10.3390/jcm10010020 |
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