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Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats
Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m(3) in a “nose only” inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796390/ https://www.ncbi.nlm.nih.gov/pubmed/33401533 http://dx.doi.org/10.3390/ijms22010416 |
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| author | Katsnelson, Boris A. Chernyshov, Ivan N. Solovyeva, Svetlana N. Minigalieva, Ilzira A. Gurvich, Vladimir B. Valamina, Irene E. Makeyev, Oleg H. Sahautdinova, Renata R. Privalova, Larisa I. Tsaregorodtseva, Anastasia E. Korotkov, Artem V. Shuman, Eugene A. Panov, Vladimir G. Sutunkova, Marina P. |
| author_facet | Katsnelson, Boris A. Chernyshov, Ivan N. Solovyeva, Svetlana N. Minigalieva, Ilzira A. Gurvich, Vladimir B. Valamina, Irene E. Makeyev, Oleg H. Sahautdinova, Renata R. Privalova, Larisa I. Tsaregorodtseva, Anastasia E. Korotkov, Artem V. Shuman, Eugene A. Panov, Vladimir G. Sutunkova, Marina P. |
| author_sort | Katsnelson, Boris A. |
| collection | PubMed |
| description | Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m(3) in a “nose only” inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all. |
| format | Online Article Text |
| id | pubmed-7796390 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77963902021-01-10 Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats Katsnelson, Boris A. Chernyshov, Ivan N. Solovyeva, Svetlana N. Minigalieva, Ilzira A. Gurvich, Vladimir B. Valamina, Irene E. Makeyev, Oleg H. Sahautdinova, Renata R. Privalova, Larisa I. Tsaregorodtseva, Anastasia E. Korotkov, Artem V. Shuman, Eugene A. Panov, Vladimir G. Sutunkova, Marina P. Int J Mol Sci Article Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m(3) in a “nose only” inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all. MDPI 2021-01-03 /pmc/articles/PMC7796390/ /pubmed/33401533 http://dx.doi.org/10.3390/ijms22010416 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Katsnelson, Boris A. Chernyshov, Ivan N. Solovyeva, Svetlana N. Minigalieva, Ilzira A. Gurvich, Vladimir B. Valamina, Irene E. Makeyev, Oleg H. Sahautdinova, Renata R. Privalova, Larisa I. Tsaregorodtseva, Anastasia E. Korotkov, Artem V. Shuman, Eugene A. Panov, Vladimir G. Sutunkova, Marina P. Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats |
| title | Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats |
| title_full | Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats |
| title_fullStr | Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats |
| title_full_unstemmed | Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats |
| title_short | Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats |
| title_sort | looking for the loael or noael concentration of nickel-oxide nanoparticles in a long-term inhalation exposure of rats |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796390/ https://www.ncbi.nlm.nih.gov/pubmed/33401533 http://dx.doi.org/10.3390/ijms22010416 |
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