Cargando…

Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?

The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammat...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiménez-Cabrera, Tania, Bautista, Mirandeli, Velázquez-González, Claudia, Jaramillo-Morales, Osmar Antonio, Guerrero-Solano, José Antonio, Urrutia-Hernández, Thania Alejandra, De la O-Arciniega, Minarda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796408/
https://www.ncbi.nlm.nih.gov/pubmed/33383701
http://dx.doi.org/10.3390/ijms22010248
_version_ 1783634674992545792
author Jiménez-Cabrera, Tania
Bautista, Mirandeli
Velázquez-González, Claudia
Jaramillo-Morales, Osmar Antonio
Guerrero-Solano, José Antonio
Urrutia-Hernández, Thania Alejandra
De la O-Arciniega, Minarda
author_facet Jiménez-Cabrera, Tania
Bautista, Mirandeli
Velázquez-González, Claudia
Jaramillo-Morales, Osmar Antonio
Guerrero-Solano, José Antonio
Urrutia-Hernández, Thania Alejandra
De la O-Arciniega, Minarda
author_sort Jiménez-Cabrera, Tania
collection PubMed
description The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long as there are no other alternatives, the trend will continue to apply multidisciplinary management, such as promote the traditional use of the Erythrina genus to manage pain and inflammation. In this sense, the Erythrina genus produces a wide range of secondary metabolites, including flavanones, isoflavones, isoflavones, and pterocarpans; these compounds are characterized by their antioxidant activity. Phenolic compounds have demonstrated their ability to suppress pro-oxidants and inhibit inflammatory signaling pathways such as MAPK, AP1, and NFκB. Although there is preclinical evidence supporting its use, the pharmacological effect mechanisms are not entirely clear. Nowadays, there is a fast advancement in knowledge of the disciplines related to drug discovery, but most of nature’s medicinal potential has not yet been harnessed. This review analyzes the decisive role that the Erythrina genus could play in managing inflammatory pain mediated by its compounds and its uses as an antioxidant.
format Online
Article
Text
id pubmed-7796408
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77964082021-01-10 Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? Jiménez-Cabrera, Tania Bautista, Mirandeli Velázquez-González, Claudia Jaramillo-Morales, Osmar Antonio Guerrero-Solano, José Antonio Urrutia-Hernández, Thania Alejandra De la O-Arciniega, Minarda Int J Mol Sci Review The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long as there are no other alternatives, the trend will continue to apply multidisciplinary management, such as promote the traditional use of the Erythrina genus to manage pain and inflammation. In this sense, the Erythrina genus produces a wide range of secondary metabolites, including flavanones, isoflavones, isoflavones, and pterocarpans; these compounds are characterized by their antioxidant activity. Phenolic compounds have demonstrated their ability to suppress pro-oxidants and inhibit inflammatory signaling pathways such as MAPK, AP1, and NFκB. Although there is preclinical evidence supporting its use, the pharmacological effect mechanisms are not entirely clear. Nowadays, there is a fast advancement in knowledge of the disciplines related to drug discovery, but most of nature’s medicinal potential has not yet been harnessed. This review analyzes the decisive role that the Erythrina genus could play in managing inflammatory pain mediated by its compounds and its uses as an antioxidant. MDPI 2020-12-29 /pmc/articles/PMC7796408/ /pubmed/33383701 http://dx.doi.org/10.3390/ijms22010248 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiménez-Cabrera, Tania
Bautista, Mirandeli
Velázquez-González, Claudia
Jaramillo-Morales, Osmar Antonio
Guerrero-Solano, José Antonio
Urrutia-Hernández, Thania Alejandra
De la O-Arciniega, Minarda
Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
title Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
title_full Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
title_fullStr Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
title_full_unstemmed Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
title_short Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
title_sort promising antioxidant activity of erythrina genus: an alternative treatment for inflammatory pain?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796408/
https://www.ncbi.nlm.nih.gov/pubmed/33383701
http://dx.doi.org/10.3390/ijms22010248
work_keys_str_mv AT jimenezcabreratania promisingantioxidantactivityoferythrinagenusanalternativetreatmentforinflammatorypain
AT bautistamirandeli promisingantioxidantactivityoferythrinagenusanalternativetreatmentforinflammatorypain
AT velazquezgonzalezclaudia promisingantioxidantactivityoferythrinagenusanalternativetreatmentforinflammatorypain
AT jaramillomoralesosmarantonio promisingantioxidantactivityoferythrinagenusanalternativetreatmentforinflammatorypain
AT guerrerosolanojoseantonio promisingantioxidantactivityoferythrinagenusanalternativetreatmentforinflammatorypain
AT urrutiahernandezthaniaalejandra promisingantioxidantactivityoferythrinagenusanalternativetreatmentforinflammatorypain
AT delaoarciniegaminarda promisingantioxidantactivityoferythrinagenusanalternativetreatmentforinflammatorypain