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Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796408/ https://www.ncbi.nlm.nih.gov/pubmed/33383701 http://dx.doi.org/10.3390/ijms22010248 |
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author | Jiménez-Cabrera, Tania Bautista, Mirandeli Velázquez-González, Claudia Jaramillo-Morales, Osmar Antonio Guerrero-Solano, José Antonio Urrutia-Hernández, Thania Alejandra De la O-Arciniega, Minarda |
author_facet | Jiménez-Cabrera, Tania Bautista, Mirandeli Velázquez-González, Claudia Jaramillo-Morales, Osmar Antonio Guerrero-Solano, José Antonio Urrutia-Hernández, Thania Alejandra De la O-Arciniega, Minarda |
author_sort | Jiménez-Cabrera, Tania |
collection | PubMed |
description | The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long as there are no other alternatives, the trend will continue to apply multidisciplinary management, such as promote the traditional use of the Erythrina genus to manage pain and inflammation. In this sense, the Erythrina genus produces a wide range of secondary metabolites, including flavanones, isoflavones, isoflavones, and pterocarpans; these compounds are characterized by their antioxidant activity. Phenolic compounds have demonstrated their ability to suppress pro-oxidants and inhibit inflammatory signaling pathways such as MAPK, AP1, and NFκB. Although there is preclinical evidence supporting its use, the pharmacological effect mechanisms are not entirely clear. Nowadays, there is a fast advancement in knowledge of the disciplines related to drug discovery, but most of nature’s medicinal potential has not yet been harnessed. This review analyzes the decisive role that the Erythrina genus could play in managing inflammatory pain mediated by its compounds and its uses as an antioxidant. |
format | Online Article Text |
id | pubmed-7796408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77964082021-01-10 Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? Jiménez-Cabrera, Tania Bautista, Mirandeli Velázquez-González, Claudia Jaramillo-Morales, Osmar Antonio Guerrero-Solano, José Antonio Urrutia-Hernández, Thania Alejandra De la O-Arciniega, Minarda Int J Mol Sci Review The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long as there are no other alternatives, the trend will continue to apply multidisciplinary management, such as promote the traditional use of the Erythrina genus to manage pain and inflammation. In this sense, the Erythrina genus produces a wide range of secondary metabolites, including flavanones, isoflavones, isoflavones, and pterocarpans; these compounds are characterized by their antioxidant activity. Phenolic compounds have demonstrated their ability to suppress pro-oxidants and inhibit inflammatory signaling pathways such as MAPK, AP1, and NFκB. Although there is preclinical evidence supporting its use, the pharmacological effect mechanisms are not entirely clear. Nowadays, there is a fast advancement in knowledge of the disciplines related to drug discovery, but most of nature’s medicinal potential has not yet been harnessed. This review analyzes the decisive role that the Erythrina genus could play in managing inflammatory pain mediated by its compounds and its uses as an antioxidant. MDPI 2020-12-29 /pmc/articles/PMC7796408/ /pubmed/33383701 http://dx.doi.org/10.3390/ijms22010248 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jiménez-Cabrera, Tania Bautista, Mirandeli Velázquez-González, Claudia Jaramillo-Morales, Osmar Antonio Guerrero-Solano, José Antonio Urrutia-Hernández, Thania Alejandra De la O-Arciniega, Minarda Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? |
title | Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? |
title_full | Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? |
title_fullStr | Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? |
title_full_unstemmed | Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? |
title_short | Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? |
title_sort | promising antioxidant activity of erythrina genus: an alternative treatment for inflammatory pain? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796408/ https://www.ncbi.nlm.nih.gov/pubmed/33383701 http://dx.doi.org/10.3390/ijms22010248 |
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