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Peptide-Based Nanomaterials for Tumor Immunotherapy

With the increasing understanding of tumor immune circulation mechanisms, tumor immunotherapy including immune checkpoint blockade has become a research hotspot, which requires the development of more accurate and more efficient drugs with fewer side effects. In line with this requirement, peptides...

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Detalles Bibliográficos
Autores principales: Li, Lingyun, Ma, Bing, Wang, Weizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796410/
https://www.ncbi.nlm.nih.gov/pubmed/33396754
http://dx.doi.org/10.3390/molecules26010132
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author Li, Lingyun
Ma, Bing
Wang, Weizhi
author_facet Li, Lingyun
Ma, Bing
Wang, Weizhi
author_sort Li, Lingyun
collection PubMed
description With the increasing understanding of tumor immune circulation mechanisms, tumor immunotherapy including immune checkpoint blockade has become a research hotspot, which requires the development of more accurate and more efficient drugs with fewer side effects. In line with this requirement, peptides with good biocompatibility, targeting, and specificity become favorable theranostic reagents, and a series of promising candidates for tumor immunotherapy based on peptides have been developed. Additionally, the advantages of nanomaterials as drug carriers such as higher affinity have been demonstrated, providing possibilities of combination therapy. In this review, we summarize the development of peptide-based nanomaterials in tumor immunotherapy from the two aspects of functionalization and self-assembly. Furthermore, new methods for peptide screening, especially machine-learning-related strategies, is also a topic we were interested in, as this forms the basis for the construction of peptide-based platforms. Peptides provide broad prospects for tumor immunotherapy and we hope that this summary can provide insight into possible avenues for future exploration.
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spelling pubmed-77964102021-01-10 Peptide-Based Nanomaterials for Tumor Immunotherapy Li, Lingyun Ma, Bing Wang, Weizhi Molecules Review With the increasing understanding of tumor immune circulation mechanisms, tumor immunotherapy including immune checkpoint blockade has become a research hotspot, which requires the development of more accurate and more efficient drugs with fewer side effects. In line with this requirement, peptides with good biocompatibility, targeting, and specificity become favorable theranostic reagents, and a series of promising candidates for tumor immunotherapy based on peptides have been developed. Additionally, the advantages of nanomaterials as drug carriers such as higher affinity have been demonstrated, providing possibilities of combination therapy. In this review, we summarize the development of peptide-based nanomaterials in tumor immunotherapy from the two aspects of functionalization and self-assembly. Furthermore, new methods for peptide screening, especially machine-learning-related strategies, is also a topic we were interested in, as this forms the basis for the construction of peptide-based platforms. Peptides provide broad prospects for tumor immunotherapy and we hope that this summary can provide insight into possible avenues for future exploration. MDPI 2020-12-30 /pmc/articles/PMC7796410/ /pubmed/33396754 http://dx.doi.org/10.3390/molecules26010132 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Lingyun
Ma, Bing
Wang, Weizhi
Peptide-Based Nanomaterials for Tumor Immunotherapy
title Peptide-Based Nanomaterials for Tumor Immunotherapy
title_full Peptide-Based Nanomaterials for Tumor Immunotherapy
title_fullStr Peptide-Based Nanomaterials for Tumor Immunotherapy
title_full_unstemmed Peptide-Based Nanomaterials for Tumor Immunotherapy
title_short Peptide-Based Nanomaterials for Tumor Immunotherapy
title_sort peptide-based nanomaterials for tumor immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796410/
https://www.ncbi.nlm.nih.gov/pubmed/33396754
http://dx.doi.org/10.3390/molecules26010132
work_keys_str_mv AT lilingyun peptidebasednanomaterialsfortumorimmunotherapy
AT mabing peptidebasednanomaterialsfortumorimmunotherapy
AT wangweizhi peptidebasednanomaterialsfortumorimmunotherapy