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Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796476/ https://www.ncbi.nlm.nih.gov/pubmed/33466437 http://dx.doi.org/10.3390/ijms22010456 |
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author | Rentschler, Simone Kaiser, Lars Deigner, Hans-Peter |
author_facet | Rentschler, Simone Kaiser, Lars Deigner, Hans-Peter |
author_sort | Rentschler, Simone |
collection | PubMed |
description | Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround times and overall efficacy. Application of an ineffective antimicrobial agent or the unnecessary use of broad-spectrum antibiotics worsens the patient prognosis and further accelerates the generation of resistant mutants. Here, we provide an overview that includes an evaluation and comparison of existing tools used to diagnose bacterial infections, together with a consideration of the underlying molecular principles and technologies. Special emphasis is placed on emerging developments that may lead to significant improvements in point of care detection and diagnosis of multi-resistant pathogens, and new directions that may be used to guide antibiotic therapy. |
format | Online Article Text |
id | pubmed-7796476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77964762021-01-10 Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance Rentschler, Simone Kaiser, Lars Deigner, Hans-Peter Int J Mol Sci Review Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround times and overall efficacy. Application of an ineffective antimicrobial agent or the unnecessary use of broad-spectrum antibiotics worsens the patient prognosis and further accelerates the generation of resistant mutants. Here, we provide an overview that includes an evaluation and comparison of existing tools used to diagnose bacterial infections, together with a consideration of the underlying molecular principles and technologies. Special emphasis is placed on emerging developments that may lead to significant improvements in point of care detection and diagnosis of multi-resistant pathogens, and new directions that may be used to guide antibiotic therapy. MDPI 2021-01-05 /pmc/articles/PMC7796476/ /pubmed/33466437 http://dx.doi.org/10.3390/ijms22010456 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rentschler, Simone Kaiser, Lars Deigner, Hans-Peter Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance |
title | Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance |
title_full | Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance |
title_fullStr | Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance |
title_full_unstemmed | Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance |
title_short | Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance |
title_sort | emerging options for the diagnosis of bacterial infections and the characterization of antimicrobial resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796476/ https://www.ncbi.nlm.nih.gov/pubmed/33466437 http://dx.doi.org/10.3390/ijms22010456 |
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