Cargando…

Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance

Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround...

Descripción completa

Detalles Bibliográficos
Autores principales: Rentschler, Simone, Kaiser, Lars, Deigner, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796476/
https://www.ncbi.nlm.nih.gov/pubmed/33466437
http://dx.doi.org/10.3390/ijms22010456
_version_ 1783634691319922688
author Rentschler, Simone
Kaiser, Lars
Deigner, Hans-Peter
author_facet Rentschler, Simone
Kaiser, Lars
Deigner, Hans-Peter
author_sort Rentschler, Simone
collection PubMed
description Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround times and overall efficacy. Application of an ineffective antimicrobial agent or the unnecessary use of broad-spectrum antibiotics worsens the patient prognosis and further accelerates the generation of resistant mutants. Here, we provide an overview that includes an evaluation and comparison of existing tools used to diagnose bacterial infections, together with a consideration of the underlying molecular principles and technologies. Special emphasis is placed on emerging developments that may lead to significant improvements in point of care detection and diagnosis of multi-resistant pathogens, and new directions that may be used to guide antibiotic therapy.
format Online
Article
Text
id pubmed-7796476
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77964762021-01-10 Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance Rentschler, Simone Kaiser, Lars Deigner, Hans-Peter Int J Mol Sci Review Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround times and overall efficacy. Application of an ineffective antimicrobial agent or the unnecessary use of broad-spectrum antibiotics worsens the patient prognosis and further accelerates the generation of resistant mutants. Here, we provide an overview that includes an evaluation and comparison of existing tools used to diagnose bacterial infections, together with a consideration of the underlying molecular principles and technologies. Special emphasis is placed on emerging developments that may lead to significant improvements in point of care detection and diagnosis of multi-resistant pathogens, and new directions that may be used to guide antibiotic therapy. MDPI 2021-01-05 /pmc/articles/PMC7796476/ /pubmed/33466437 http://dx.doi.org/10.3390/ijms22010456 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rentschler, Simone
Kaiser, Lars
Deigner, Hans-Peter
Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
title Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
title_full Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
title_fullStr Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
title_full_unstemmed Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
title_short Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
title_sort emerging options for the diagnosis of bacterial infections and the characterization of antimicrobial resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796476/
https://www.ncbi.nlm.nih.gov/pubmed/33466437
http://dx.doi.org/10.3390/ijms22010456
work_keys_str_mv AT rentschlersimone emergingoptionsforthediagnosisofbacterialinfectionsandthecharacterizationofantimicrobialresistance
AT kaiserlars emergingoptionsforthediagnosisofbacterialinfectionsandthecharacterizationofantimicrobialresistance
AT deignerhanspeter emergingoptionsforthediagnosisofbacterialinfectionsandthecharacterizationofantimicrobialresistance