Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study

There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation decisions during the trials. The majority of these proposals are model-based:...

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Detalles Bibliográficos
Autores principales: Mozgunov, Pavel, Knight, Rochelle, Barnett, Helen, Jaki, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796482/
https://www.ncbi.nlm.nih.gov/pubmed/33466469
http://dx.doi.org/10.3390/ijerph18010345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796482/
https://www.ncbi.nlm.nih.gov/pubmed/33466469
http://dx.doi.org/10.3390/ijerph18010345

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