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Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study
There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation decisions during the trials. The majority of these proposals are model-based:...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796482/ https://www.ncbi.nlm.nih.gov/pubmed/33466469 http://dx.doi.org/10.3390/ijerph18010345 |