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Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults

There is conflicting evidence regarding the association between insomnia and the onset of mild cognitive impairment (MCI) or dementia. This study aimed to evaluate if time-varying insomnia is associated with the development of MCI and dementia. Data from the Health and Retirement Study (n = 13,833)...

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Autores principales: Resciniti, Nicholas V., Yelverton, Valerie, Kase, Bezawit E., Zhang, Jiajia, Lohman, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796486/
https://www.ncbi.nlm.nih.gov/pubmed/33466468
http://dx.doi.org/10.3390/ijerph18010351
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author Resciniti, Nicholas V.
Yelverton, Valerie
Kase, Bezawit E.
Zhang, Jiajia
Lohman, Matthew C.
author_facet Resciniti, Nicholas V.
Yelverton, Valerie
Kase, Bezawit E.
Zhang, Jiajia
Lohman, Matthew C.
author_sort Resciniti, Nicholas V.
collection PubMed
description There is conflicting evidence regarding the association between insomnia and the onset of mild cognitive impairment (MCI) or dementia. This study aimed to evaluate if time-varying insomnia is associated with the development of MCI and dementia. Data from the Health and Retirement Study (n = 13,833) from 2002 to 2014 were used (59.4% female). The Brief Insomnia Questionnaire was used to identify insomnia symptoms which were compiled in an insomnia severity index, ranging from 0 to 4. In analysis, participants’ symptoms could vary from wave-to-wave. Dementia was defined using results from the Health and Retirement Study (HRS) global cognitive assessment tool. Respondents were classified as either having dementia, MCI, or being cognitively healthy. Cox proportional hazards models with time-dependent exposure using the counting process (start-stop time) were used for analysis. For each one-unit increase in the insomnia symptom index, there was a 5-percent greater hazard of MCI (HR = 1.05; 95% CI: 1.04–1.06) and dementia (HR = 1.05; 95% CI: 1.03–1.05), after fully adjusting. Using a nationally representative sample of adults age 51 and older, this study found that time-varying insomnia symptoms are associated with risk of MCI and dementia. This highlights the importance of identifying sleep disturbances and their change over time as potentially important risk factors for MCI and dementia.
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spelling pubmed-77964862021-01-10 Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults Resciniti, Nicholas V. Yelverton, Valerie Kase, Bezawit E. Zhang, Jiajia Lohman, Matthew C. Int J Environ Res Public Health Article There is conflicting evidence regarding the association between insomnia and the onset of mild cognitive impairment (MCI) or dementia. This study aimed to evaluate if time-varying insomnia is associated with the development of MCI and dementia. Data from the Health and Retirement Study (n = 13,833) from 2002 to 2014 were used (59.4% female). The Brief Insomnia Questionnaire was used to identify insomnia symptoms which were compiled in an insomnia severity index, ranging from 0 to 4. In analysis, participants’ symptoms could vary from wave-to-wave. Dementia was defined using results from the Health and Retirement Study (HRS) global cognitive assessment tool. Respondents were classified as either having dementia, MCI, or being cognitively healthy. Cox proportional hazards models with time-dependent exposure using the counting process (start-stop time) were used for analysis. For each one-unit increase in the insomnia symptom index, there was a 5-percent greater hazard of MCI (HR = 1.05; 95% CI: 1.04–1.06) and dementia (HR = 1.05; 95% CI: 1.03–1.05), after fully adjusting. Using a nationally representative sample of adults age 51 and older, this study found that time-varying insomnia symptoms are associated with risk of MCI and dementia. This highlights the importance of identifying sleep disturbances and their change over time as potentially important risk factors for MCI and dementia. MDPI 2021-01-05 2021-01 /pmc/articles/PMC7796486/ /pubmed/33466468 http://dx.doi.org/10.3390/ijerph18010351 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Resciniti, Nicholas V.
Yelverton, Valerie
Kase, Bezawit E.
Zhang, Jiajia
Lohman, Matthew C.
Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults
title Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults
title_full Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults
title_fullStr Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults
title_full_unstemmed Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults
title_short Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults
title_sort time-varying insomnia symptoms and incidence of cognitive impairment and dementia among older us adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796486/
https://www.ncbi.nlm.nih.gov/pubmed/33466468
http://dx.doi.org/10.3390/ijerph18010351
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