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Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal)
INTRODUCTION: COVID-19 has spread rapidly since its emergence in China and is currently a global health issue. Its definitive diagnosis is made by PCR on nasopharyngeal swabs. However, this diagnostic test has low sensitivity with delayed results. Hence, thoracic computed tomography represents an in...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796847/ https://www.ncbi.nlm.nih.gov/pubmed/33456646 http://dx.doi.org/10.11604/pamj.supp.2020.37.1.26140 |
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author | Niang, Ibrahima Diallo, Ibrahima Diouf, Joseph Coumba Ndoffene Ly, Mamadou Toure, Mouhamadou Hamine Diouf, Khadidiatou Ndiaye Niang, Fallou Galass Faye, Ibrahima Ndao, Mama Akpo, Geraud Deme, Hamidou Diop, Abdoulaye Dione Ba, Sokhna Niang, Elhadji |
author_facet | Niang, Ibrahima Diallo, Ibrahima Diouf, Joseph Coumba Ndoffene Ly, Mamadou Toure, Mouhamadou Hamine Diouf, Khadidiatou Ndiaye Niang, Fallou Galass Faye, Ibrahima Ndao, Mama Akpo, Geraud Deme, Hamidou Diop, Abdoulaye Dione Ba, Sokhna Niang, Elhadji |
author_sort | Niang, Ibrahima |
collection | PubMed |
description | INTRODUCTION: COVID-19 has spread rapidly since its emergence in China and is currently a global health issue. Its definitive diagnosis is made by PCR on nasopharyngeal swabs. However, this diagnostic test has low sensitivity with delayed results. Hence, thoracic computed tomography represents an interesting alternative. The aims of this study were to assess the frequency of computed tomography (CT) lesions suggestive of COVID-19 and to compare the results of CT and PCR test. METHODS: a prospective study carried out over15 working days and involved 47 patients. These patients were recruited based on the presence of at least 2 clinical signs of COVID-19. Chest CT without contrast according to the “LOW-DOSE” protocol was performed. A PCR test on nasopharyngeal swabs was done in patients with signs suggestive of COVID on CT. A serological test was performed in case of a discrepancy between the CT and PCR results. RESULTS: thoracic CT was abnormal in 38 patients and normal in 9 patients. Lesions suggestive of COVID-19 have been identified in 32 patients. Two patients had lesions of non-specific pneumonia. Tuberculosis lesions were visualized in 3 patients. One patient had lesions of interstitial pneumonia. The mean DLP was 59 mGy.cm with extremes of 25 and 95 mGy.cm. Ground-glass opacity was present in 100% of COVID-19 suspects on CT. The results of the PCR test were the same than CT in 12 patients. The positive predictive value for CT was 37.5%. In 20 patients with COVID lesions on CT, the PCR test was negative with a false positive rate of 62.5%. In the patients with negative PCR test, 4 had a serological test for COVID-19 and this test was positive in 3. CONCLUSION: low-dose chest CT can reduce radiation exposure in COVID-19 patients who are at risk of cumulative dose due to repetitive exam. CT can identify lesions suggestive of COVID-19. It also enables the triage of patients by identifying other diagnoses. |
format | Online Article Text |
id | pubmed-7796847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-77968472021-01-15 Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal) Niang, Ibrahima Diallo, Ibrahima Diouf, Joseph Coumba Ndoffene Ly, Mamadou Toure, Mouhamadou Hamine Diouf, Khadidiatou Ndiaye Niang, Fallou Galass Faye, Ibrahima Ndao, Mama Akpo, Geraud Deme, Hamidou Diop, Abdoulaye Dione Ba, Sokhna Niang, Elhadji Pan Afr Med J Research INTRODUCTION: COVID-19 has spread rapidly since its emergence in China and is currently a global health issue. Its definitive diagnosis is made by PCR on nasopharyngeal swabs. However, this diagnostic test has low sensitivity with delayed results. Hence, thoracic computed tomography represents an interesting alternative. The aims of this study were to assess the frequency of computed tomography (CT) lesions suggestive of COVID-19 and to compare the results of CT and PCR test. METHODS: a prospective study carried out over15 working days and involved 47 patients. These patients were recruited based on the presence of at least 2 clinical signs of COVID-19. Chest CT without contrast according to the “LOW-DOSE” protocol was performed. A PCR test on nasopharyngeal swabs was done in patients with signs suggestive of COVID on CT. A serological test was performed in case of a discrepancy between the CT and PCR results. RESULTS: thoracic CT was abnormal in 38 patients and normal in 9 patients. Lesions suggestive of COVID-19 have been identified in 32 patients. Two patients had lesions of non-specific pneumonia. Tuberculosis lesions were visualized in 3 patients. One patient had lesions of interstitial pneumonia. The mean DLP was 59 mGy.cm with extremes of 25 and 95 mGy.cm. Ground-glass opacity was present in 100% of COVID-19 suspects on CT. The results of the PCR test were the same than CT in 12 patients. The positive predictive value for CT was 37.5%. In 20 patients with COVID lesions on CT, the PCR test was negative with a false positive rate of 62.5%. In the patients with negative PCR test, 4 had a serological test for COVID-19 and this test was positive in 3. CONCLUSION: low-dose chest CT can reduce radiation exposure in COVID-19 patients who are at risk of cumulative dose due to repetitive exam. CT can identify lesions suggestive of COVID-19. It also enables the triage of patients by identifying other diagnoses. The African Field Epidemiology Network 2020-10-13 /pmc/articles/PMC7796847/ /pubmed/33456646 http://dx.doi.org/10.11604/pamj.supp.2020.37.1.26140 Text en Copyright: Ibrahima Niang et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Niang, Ibrahima Diallo, Ibrahima Diouf, Joseph Coumba Ndoffene Ly, Mamadou Toure, Mouhamadou Hamine Diouf, Khadidiatou Ndiaye Niang, Fallou Galass Faye, Ibrahima Ndao, Mama Akpo, Geraud Deme, Hamidou Diop, Abdoulaye Dione Ba, Sokhna Niang, Elhadji Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal) |
title | Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal) |
title_full | Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal) |
title_fullStr | Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal) |
title_full_unstemmed | Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal) |
title_short | Tri et détection du COVID-19 par TDM thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de Fann (Dakar-Sénégal) |
title_sort | tri et détection du covid-19 par tdm thoracique low-dose chez des patients tout-venant au service de radiologie de l´hôpital de fann (dakar-sénégal) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796847/ https://www.ncbi.nlm.nih.gov/pubmed/33456646 http://dx.doi.org/10.11604/pamj.supp.2020.37.1.26140 |
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