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Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1(+) prostate luminal cells
Prostate adenocarcinoma undergoes neuroendocrine differentiation to acquire resistance toward anti-hormonal therapies. The underlying mechanisms have been investigated extensively, among which Sox2 has been shown to play a critical role. However, genetic evidence in mouse models for prostate cancer...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796948/ https://www.ncbi.nlm.nih.gov/pubmed/33110232 http://dx.doi.org/10.1038/s41388-020-01526-2 |