The association between tumor mutational burden and prognosis is dependent on treatment context

In multiple cancer types, high tumor mutational burden (TMB) is associated with longer survival after treatment with immune checkpoint inhibitors (ICI). The association of TMB with survival outside of the immunotherapy context is poorly understood. We analyzed 10,233 patients (80% non-ICI-treated, 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Valero, Cristina, Lee, Mark, Hoen, Douglas, Wang, Jingming, Nadeem, Zaineb, Patel, Neal, Postow, Michael A., Shoushtari, Alexander N., Plitas, George, Balachandran, Vinod P., Smith, J. Joshua, Crago, Aimee M., Roche, Kara C. Long, Kelly, Daniel W., Samstein, Robert M., Rana, Satshil, Ganly, Ian, Wong, Richard J., Hakimi, A. Ari, Berger, Michael F., Zehir, Ahmet, Solit, David B., Ladanyi, Marc, Riaz, Nadeem, Chan, Timothy A., Seshan, Venkatraman E., Morris, Luc G.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796993/
https://www.ncbi.nlm.nih.gov/pubmed/33398197
http://dx.doi.org/10.1038/s41588-020-00752-4
_version_ 1783634779727462400
author Valero, Cristina
Lee, Mark
Hoen, Douglas
Wang, Jingming
Nadeem, Zaineb
Patel, Neal
Postow, Michael A.
Shoushtari, Alexander N.
Plitas, George
Balachandran, Vinod P.
Smith, J. Joshua
Crago, Aimee M.
Roche, Kara C. Long
Kelly, Daniel W.
Samstein, Robert M.
Rana, Satshil
Ganly, Ian
Wong, Richard J.
Hakimi, A. Ari
Berger, Michael F.
Zehir, Ahmet
Solit, David B.
Ladanyi, Marc
Riaz, Nadeem
Chan, Timothy A.
Seshan, Venkatraman E.
Morris, Luc G.T.
author_facet Valero, Cristina
Lee, Mark
Hoen, Douglas
Wang, Jingming
Nadeem, Zaineb
Patel, Neal
Postow, Michael A.
Shoushtari, Alexander N.
Plitas, George
Balachandran, Vinod P.
Smith, J. Joshua
Crago, Aimee M.
Roche, Kara C. Long
Kelly, Daniel W.
Samstein, Robert M.
Rana, Satshil
Ganly, Ian
Wong, Richard J.
Hakimi, A. Ari
Berger, Michael F.
Zehir, Ahmet
Solit, David B.
Ladanyi, Marc
Riaz, Nadeem
Chan, Timothy A.
Seshan, Venkatraman E.
Morris, Luc G.T.
author_sort Valero, Cristina
collection PubMed
description In multiple cancer types, high tumor mutational burden (TMB) is associated with longer survival after treatment with immune checkpoint inhibitors (ICI). The association of TMB with survival outside of the immunotherapy context is poorly understood. We analyzed 10,233 patients (80% non-ICI-treated, 20% ICI-treated) with 17 cancer types, before/without ICI treatment, or after ICI treatment. In non-ICI-treated patients, higher TMB (higher percentile within cancer type) was not associated with better prognosis; in fact, in many cancer types, higher TMB was associated with poorer survival, in contrast to ICI-treated patients, in whom higher TMB was associated with longer survival.
format Online
Article
Text
id pubmed-7796993
institution National Center for Biotechnology Information
language English
publishDate 2021
record_format MEDLINE/PubMed
spelling pubmed-77969932021-07-04 The association between tumor mutational burden and prognosis is dependent on treatment context Valero, Cristina Lee, Mark Hoen, Douglas Wang, Jingming Nadeem, Zaineb Patel, Neal Postow, Michael A. Shoushtari, Alexander N. Plitas, George Balachandran, Vinod P. Smith, J. Joshua Crago, Aimee M. Roche, Kara C. Long Kelly, Daniel W. Samstein, Robert M. Rana, Satshil Ganly, Ian Wong, Richard J. Hakimi, A. Ari Berger, Michael F. Zehir, Ahmet Solit, David B. Ladanyi, Marc Riaz, Nadeem Chan, Timothy A. Seshan, Venkatraman E. Morris, Luc G.T. Nat Genet Article In multiple cancer types, high tumor mutational burden (TMB) is associated with longer survival after treatment with immune checkpoint inhibitors (ICI). The association of TMB with survival outside of the immunotherapy context is poorly understood. We analyzed 10,233 patients (80% non-ICI-treated, 20% ICI-treated) with 17 cancer types, before/without ICI treatment, or after ICI treatment. In non-ICI-treated patients, higher TMB (higher percentile within cancer type) was not associated with better prognosis; in fact, in many cancer types, higher TMB was associated with poorer survival, in contrast to ICI-treated patients, in whom higher TMB was associated with longer survival. 2021-01-04 2021-01 /pmc/articles/PMC7796993/ /pubmed/33398197 http://dx.doi.org/10.1038/s41588-020-00752-4 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Valero, Cristina
Lee, Mark
Hoen, Douglas
Wang, Jingming
Nadeem, Zaineb
Patel, Neal
Postow, Michael A.
Shoushtari, Alexander N.
Plitas, George
Balachandran, Vinod P.
Smith, J. Joshua
Crago, Aimee M.
Roche, Kara C. Long
Kelly, Daniel W.
Samstein, Robert M.
Rana, Satshil
Ganly, Ian
Wong, Richard J.
Hakimi, A. Ari
Berger, Michael F.
Zehir, Ahmet
Solit, David B.
Ladanyi, Marc
Riaz, Nadeem
Chan, Timothy A.
Seshan, Venkatraman E.
Morris, Luc G.T.
The association between tumor mutational burden and prognosis is dependent on treatment context
title The association between tumor mutational burden and prognosis is dependent on treatment context
title_full The association between tumor mutational burden and prognosis is dependent on treatment context
title_fullStr The association between tumor mutational burden and prognosis is dependent on treatment context
title_full_unstemmed The association between tumor mutational burden and prognosis is dependent on treatment context
title_short The association between tumor mutational burden and prognosis is dependent on treatment context
title_sort association between tumor mutational burden and prognosis is dependent on treatment context
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796993/
https://www.ncbi.nlm.nih.gov/pubmed/33398197
http://dx.doi.org/10.1038/s41588-020-00752-4
work_keys_str_mv AT valerocristina theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT leemark theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT hoendouglas theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT wangjingming theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT nadeemzaineb theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT patelneal theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT postowmichaela theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT shoushtarialexandern theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT plitasgeorge theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT balachandranvinodp theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT smithjjoshua theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT cragoaimeem theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT rochekaraclong theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT kellydanielw theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT samsteinrobertm theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT ranasatshil theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT ganlyian theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT wongrichardj theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT hakimiaari theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT bergermichaelf theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT zehirahmet theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT solitdavidb theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT ladanyimarc theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT riaznadeem theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT chantimothya theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT seshanvenkatramane theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT morrislucgt theassociationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT valerocristina associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT leemark associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT hoendouglas associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT wangjingming associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT nadeemzaineb associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT patelneal associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT postowmichaela associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT shoushtarialexandern associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT plitasgeorge associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT balachandranvinodp associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT smithjjoshua associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT cragoaimeem associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT rochekaraclong associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT kellydanielw associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT samsteinrobertm associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT ranasatshil associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT ganlyian associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT wongrichardj associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT hakimiaari associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT bergermichaelf associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT zehirahmet associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT solitdavidb associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT ladanyimarc associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT riaznadeem associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT chantimothya associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT seshanvenkatramane associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext
AT morrislucgt associationbetweentumormutationalburdenandprognosisisdependentontreatmentcontext

Ejemplares similares