Deploying MMEJ using MENdel in precision gene editing applications for gene therapy and functional genomics

Gene-editing experiments commonly elicit the error-prone non-homologous end joining for DNA double-strand break (DSB) repair. Microhomology-mediated end joining (MMEJ) can generate more predictable outcomes for functional genomic and somatic therapeutic applications. We compared three DSB repair pre...

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Detalles Bibliográficos
Autores principales: Martínez-Gálvez, Gabriel, Joshi, Parnal, Friedberg, Iddo, Manduca, Armando, Ekker, Stephen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797032/
https://www.ncbi.nlm.nih.gov/pubmed/33305328
http://dx.doi.org/10.1093/nar/gkaa1156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797032/
https://www.ncbi.nlm.nih.gov/pubmed/33305328
http://dx.doi.org/10.1093/nar/gkaa1156

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