APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A

Many APOBEC cytidine deaminase members are known to induce ‘off-target’ cytidine deaminations in 5′TC motifs in genomic DNA that contribute to cancer evolution. In this report, we characterized APOBEC1, which is a possible cancer related APOBEC since APOBEC1 mRNA is highly expressed in certain types...

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Detalles Bibliográficos
Autores principales: Wong, Lai, Vizeacoumar, Frederick S, Vizeacoumar, Franco J, Chelico, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797036/
https://www.ncbi.nlm.nih.gov/pubmed/33330905
http://dx.doi.org/10.1093/nar/gkaa1201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797036/
https://www.ncbi.nlm.nih.gov/pubmed/33330905
http://dx.doi.org/10.1093/nar/gkaa1201

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