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Flanking sequence preference modulates de novo DNA methylation in the mouse genome

Mammalian de novo DNA methyltransferases (DNMT) are responsible for the establishment of cell-type-specific DNA methylation in healthy and diseased tissues. Through genome-wide analysis of de novo methylation activity in murine stem cells we uncover that DNMT3A prefers to methylate CpGs followed by...

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Detalles Bibliográficos
Autores principales:	Mallona, Izaskun, Ilie, Ioana Mariuca, Karemaker, Ino Dominiek, Butz, Stefan, Manzo, Massimiliano, Caflisch, Amedeo, Baubec, Tuncay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797059/ https://www.ncbi.nlm.nih.gov/pubmed/33290556 http://dx.doi.org/10.1093/nar/gkaa1168

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