High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)

Nucleic acid therapeutics (NATs) have proven useful in promoting the degradation of specific transcripts, modifying gene expression, and regulating mRNA splicing. In each situation, efficient delivery of nucleic acids to cells, tissues and intracellular compartments is crucial—both for optimizing ef...

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Detalles Bibliográficos
Autores principales: He, Cuiwen, Migawa, Michael T, Chen, Kai, Weston, Thomas A, Tanowitz, Michael, Song, Wenxin, Guagliardo, Paul, Iyer, K Swaminathan, Bennett, C Frank, Fong, Loren G, Seth, Punit P, Young, Stephen G, Jiang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797060/
https://www.ncbi.nlm.nih.gov/pubmed/33275144
http://dx.doi.org/10.1093/nar/gkaa1112

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