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Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis

In the Gram-positive Firmicute bacterium Bacillus subtilis, amino acid starvation induces synthesis of the alarmone (p)ppGpp by the RelA/SpoT Homolog factor Rel. This bifunctional enzyme is capable of both synthesizing and hydrolysing (p)ppGpp. To detect amino acid deficiency, Rel monitors the amino...

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Detalles Bibliográficos
Autores principales:	Takada, Hiraku, Roghanian, Mohammad, Caballero-Montes, Julien, Van Nerom, Katleen, Jimmy, Steffi, Kudrin, Pavel, Trebini, Fabio, Murayama, Rikinori, Akanuma, Genki, Garcia-Pino, Abel, Hauryliuk, Vasili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797070/ https://www.ncbi.nlm.nih.gov/pubmed/33330919 http://dx.doi.org/10.1093/nar/gkaa1187

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