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Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress
Early life adversity is widely recognized as a key risk factor for early developmental perturbations and contributes to the presentation of neuropsychiatric disorders in adulthood. Neurodevelopmental disorders exhibit a strong sex bias in susceptibility, presentation, onset, and severity, although t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797134/ https://www.ncbi.nlm.nih.gov/pubmed/33422127 http://dx.doi.org/10.1186/s13293-020-00356-x |
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author | Jašarević, Eldin Hecht, Patrick M. Fritsche, Kevin L. Geary, David C. Rivera, Rocío M. Beversdorf, David Q. |
author_facet | Jašarević, Eldin Hecht, Patrick M. Fritsche, Kevin L. Geary, David C. Rivera, Rocío M. Beversdorf, David Q. |
author_sort | Jašarević, Eldin |
collection | PubMed |
description | Early life adversity is widely recognized as a key risk factor for early developmental perturbations and contributes to the presentation of neuropsychiatric disorders in adulthood. Neurodevelopmental disorders exhibit a strong sex bias in susceptibility, presentation, onset, and severity, although the underlying mechanisms conferring vulnerability are not well understood. Environmental perturbations during pregnancy, such as malnutrition or stress, have been associated with sex-specific reprogramming that contribute to increased disease risk in adulthood, whereby stress and nutritional insufficiency may be additive and further exacerbate poor offspring outcomes. To determine whether maternal supplementation of docosahexanoic acid (DHA) exerts an effect on offspring outcome following exposure to early prenatal stress (EPS), dams were fed a purified 10:1 omega-6/omega-3 diet supplemented with either 1.0% preformed DHA/kg feed weight (DHA-enriched) or no additional DHA (denoted as the control diet, CTL). Dams were administered chronic variable stress during the first week of pregnancy (embryonic day, E0.5–7.5), and developmental milestones were assessed at E 12.5. Exposure to early prenatal stress (EPS) decreased placenta and embryo weight in males, but not females, exposed to the CTL diet. DHA enrichment reversed the sex-specific decrease in placenta and embryo weight following EPS. Early prenatal exposure upregulated expression of genes associated with oxygen and nutrient transport, including hypoxia inducible factor 3α (HIF3α), peroxisome proliferator-activated receptor alpha (PPARα), and insulin-like growth binding factor 1 (IGFBP1), in the placenta of CTL diet males exposed to EPS. DHA enrichment in EPS-exposed animals abrogated the male-specific upregulation of PPARα, HIF3α, and IGFBP1. Taken together, these studies suggest that maternal dietary DHA enrichment may buffer against maternal stress programming of sex-specific outcomes during early development. |
format | Online Article Text |
id | pubmed-7797134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77971342021-01-11 Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress Jašarević, Eldin Hecht, Patrick M. Fritsche, Kevin L. Geary, David C. Rivera, Rocío M. Beversdorf, David Q. Biol Sex Differ Research Early life adversity is widely recognized as a key risk factor for early developmental perturbations and contributes to the presentation of neuropsychiatric disorders in adulthood. Neurodevelopmental disorders exhibit a strong sex bias in susceptibility, presentation, onset, and severity, although the underlying mechanisms conferring vulnerability are not well understood. Environmental perturbations during pregnancy, such as malnutrition or stress, have been associated with sex-specific reprogramming that contribute to increased disease risk in adulthood, whereby stress and nutritional insufficiency may be additive and further exacerbate poor offspring outcomes. To determine whether maternal supplementation of docosahexanoic acid (DHA) exerts an effect on offspring outcome following exposure to early prenatal stress (EPS), dams were fed a purified 10:1 omega-6/omega-3 diet supplemented with either 1.0% preformed DHA/kg feed weight (DHA-enriched) or no additional DHA (denoted as the control diet, CTL). Dams were administered chronic variable stress during the first week of pregnancy (embryonic day, E0.5–7.5), and developmental milestones were assessed at E 12.5. Exposure to early prenatal stress (EPS) decreased placenta and embryo weight in males, but not females, exposed to the CTL diet. DHA enrichment reversed the sex-specific decrease in placenta and embryo weight following EPS. Early prenatal exposure upregulated expression of genes associated with oxygen and nutrient transport, including hypoxia inducible factor 3α (HIF3α), peroxisome proliferator-activated receptor alpha (PPARα), and insulin-like growth binding factor 1 (IGFBP1), in the placenta of CTL diet males exposed to EPS. DHA enrichment in EPS-exposed animals abrogated the male-specific upregulation of PPARα, HIF3α, and IGFBP1. Taken together, these studies suggest that maternal dietary DHA enrichment may buffer against maternal stress programming of sex-specific outcomes during early development. BioMed Central 2021-01-09 /pmc/articles/PMC7797134/ /pubmed/33422127 http://dx.doi.org/10.1186/s13293-020-00356-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Jašarević, Eldin Hecht, Patrick M. Fritsche, Kevin L. Geary, David C. Rivera, Rocío M. Beversdorf, David Q. Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress |
title | Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress |
title_full | Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress |
title_fullStr | Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress |
title_full_unstemmed | Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress |
title_short | Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress |
title_sort | maternal dha supplementation influences sex-specific disruption of placental gene expression following early prenatal stress |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797134/ https://www.ncbi.nlm.nih.gov/pubmed/33422127 http://dx.doi.org/10.1186/s13293-020-00356-x |
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