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Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis

BACKGROUND: Ulcerative colitis (UC) is one of the most challenging human diseases. Natural shikonin (SK) and its derivatives (with have higher accumulation) isolated from the root of Lithospermum erythrorhizon have numerous beneficial effects, such as wound healing and anti-inflammatory activities....

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Autores principales: Han, Hongwei, Sun, Wenxue, Feng, Lu, Wen, Zhongling, Yang, Minkai, Ma, Yingying, Fu, Jiangyan, Ma, Xiaopeng, Xu, Xinhong, Wang, Zhaoyue, Yin, Tongming, Wang, Xiao-Ming, Lu, Gui-Hua, Qi, Jin-Liang, Lin, Hongyan, Yang, Yonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797173/
https://www.ncbi.nlm.nih.gov/pubmed/33505807
http://dx.doi.org/10.7717/peerj.10675
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author Han, Hongwei
Sun, Wenxue
Feng, Lu
Wen, Zhongling
Yang, Minkai
Ma, Yingying
Fu, Jiangyan
Ma, Xiaopeng
Xu, Xinhong
Wang, Zhaoyue
Yin, Tongming
Wang, Xiao-Ming
Lu, Gui-Hua
Qi, Jin-Liang
Lin, Hongyan
Yang, Yonghua
author_facet Han, Hongwei
Sun, Wenxue
Feng, Lu
Wen, Zhongling
Yang, Minkai
Ma, Yingying
Fu, Jiangyan
Ma, Xiaopeng
Xu, Xinhong
Wang, Zhaoyue
Yin, Tongming
Wang, Xiao-Ming
Lu, Gui-Hua
Qi, Jin-Liang
Lin, Hongyan
Yang, Yonghua
author_sort Han, Hongwei
collection PubMed
description BACKGROUND: Ulcerative colitis (UC) is one of the most challenging human diseases. Natural shikonin (SK) and its derivatives (with have higher accumulation) isolated from the root of Lithospermum erythrorhizon have numerous beneficial effects, such as wound healing and anti-inflammatory activities. Some researchers have reported that hydroxynaphthoquinone mixture (HM) and SK attenuate the acute UC induced by dextran sulfate sodium (DSS). However, no existing study has systemically investigated the effectiveness of SK and other hydroxynaphthoquinone natural derivative monomers on UC. METHODS: In this study, mice were treated with SK and its derivatives (25 mg/kg) and mesalazine (200 mg/kg) after DSS administration daily for one week. Disease progression was monitored daily by observing the changes in clinical signs and body weight. RESULTS: Intragastric administration natural single naphthoquinone attenuated the malignant symptoms induced by DSS. SK or its derivatives remarkably suppressed the serum levels of pro-inflammatory cytokines while increasing the inflammatory cytokine interleukin (IL)-10 . Additionally, both SK and alkanin restrained the activities of cyclooxygenase-2 (COX-2), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) in serum and colonic tissues. SK and its derivatives inhibited the activation of nucleotide binding oligomerization domain-like receptors (NLRP3) inflammasome and NF-κB signaling pathway, thereby relieving the DSS-induced disruption of epithelial tight junction (TJ) in colonic tissues. CONCLUSIONS: Our findings shed more lights on the pharmacological efficacy of SK and its derivatives in UC against inflammation and mucosal barrier damage.
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spelling pubmed-77971732021-01-26 Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis Han, Hongwei Sun, Wenxue Feng, Lu Wen, Zhongling Yang, Minkai Ma, Yingying Fu, Jiangyan Ma, Xiaopeng Xu, Xinhong Wang, Zhaoyue Yin, Tongming Wang, Xiao-Ming Lu, Gui-Hua Qi, Jin-Liang Lin, Hongyan Yang, Yonghua PeerJ Drugs and Devices BACKGROUND: Ulcerative colitis (UC) is one of the most challenging human diseases. Natural shikonin (SK) and its derivatives (with have higher accumulation) isolated from the root of Lithospermum erythrorhizon have numerous beneficial effects, such as wound healing and anti-inflammatory activities. Some researchers have reported that hydroxynaphthoquinone mixture (HM) and SK attenuate the acute UC induced by dextran sulfate sodium (DSS). However, no existing study has systemically investigated the effectiveness of SK and other hydroxynaphthoquinone natural derivative monomers on UC. METHODS: In this study, mice were treated with SK and its derivatives (25 mg/kg) and mesalazine (200 mg/kg) after DSS administration daily for one week. Disease progression was monitored daily by observing the changes in clinical signs and body weight. RESULTS: Intragastric administration natural single naphthoquinone attenuated the malignant symptoms induced by DSS. SK or its derivatives remarkably suppressed the serum levels of pro-inflammatory cytokines while increasing the inflammatory cytokine interleukin (IL)-10 . Additionally, both SK and alkanin restrained the activities of cyclooxygenase-2 (COX-2), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) in serum and colonic tissues. SK and its derivatives inhibited the activation of nucleotide binding oligomerization domain-like receptors (NLRP3) inflammasome and NF-κB signaling pathway, thereby relieving the DSS-induced disruption of epithelial tight junction (TJ) in colonic tissues. CONCLUSIONS: Our findings shed more lights on the pharmacological efficacy of SK and its derivatives in UC against inflammation and mucosal barrier damage. PeerJ Inc. 2021-01-07 /pmc/articles/PMC7797173/ /pubmed/33505807 http://dx.doi.org/10.7717/peerj.10675 Text en ©2021 Han et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Drugs and Devices
Han, Hongwei
Sun, Wenxue
Feng, Lu
Wen, Zhongling
Yang, Minkai
Ma, Yingying
Fu, Jiangyan
Ma, Xiaopeng
Xu, Xinhong
Wang, Zhaoyue
Yin, Tongming
Wang, Xiao-Ming
Lu, Gui-Hua
Qi, Jin-Liang
Lin, Hongyan
Yang, Yonghua
Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
title Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
title_full Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
title_fullStr Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
title_full_unstemmed Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
title_short Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
title_sort differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
topic Drugs and Devices
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797173/
https://www.ncbi.nlm.nih.gov/pubmed/33505807
http://dx.doi.org/10.7717/peerj.10675
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