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Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes

AIM: In cardiomyocytes, transverse tubules (T-tubules) associate with the sarcoplasmic reticulum (SR), forming junctional membrane complexes (JMCs) where L-type calcium channels (LTCCs) are juxtaposed to Ryanodine receptors (RyR). Junctophilin-2 (JPH2) supports the assembly of JMCs by tethering T-tu...

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Detalles Bibliográficos
Autores principales:	Poulet, Claire, Sanchez-Alonso, Jose, Swiatlowska, Pamela, Mouy, Florence, Lucarelli, Carla, Alvarez-Laviada, Anita, Gross, Polina, Terracciano, Cesare, Houser, Steven, Gorelik, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797210/ https://www.ncbi.nlm.nih.gov/pubmed/32053184 http://dx.doi.org/10.1093/cvr/cvaa033

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