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Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis
INTRODUCTION: There is growing evidence of a higher than expected prevalence of retinopathy in prediabetes. This paper presents the protocol of a systematic review and meta-analysis of retinopathy in prediabetes. The aim of the review is to estimate the prevalence of retinopathy in prediabetes and t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797244/ https://www.ncbi.nlm.nih.gov/pubmed/33414145 http://dx.doi.org/10.1136/bmjopen-2020-040997 |
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author | Kirthi, Varo Nderitu, Paul Alam, Uazman Evans, Jennifer Nevitt, Sarah Malik, Rayaz A Jackson, Timothy L |
author_facet | Kirthi, Varo Nderitu, Paul Alam, Uazman Evans, Jennifer Nevitt, Sarah Malik, Rayaz A Jackson, Timothy L |
author_sort | Kirthi, Varo |
collection | PubMed |
description | INTRODUCTION: There is growing evidence of a higher than expected prevalence of retinopathy in prediabetes. This paper presents the protocol of a systematic review and meta-analysis of retinopathy in prediabetes. The aim of the review is to estimate the prevalence of retinopathy in prediabetes and to summarise the current data. METHODS AND ANALYSIS: This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. A comprehensive electronic bibliographic search will be conducted in MEDLINE, EMBASE, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Google Scholar and the Cochrane Library. Eligible studies will report prevalence data for retinopathy on fundus photography in adults with prediabetes. No time restrictions will be placed on the date of publication. Screening for eligible studies and data extraction will be conducted by two reviewers independently, using predefined inclusion criteria and prepiloted data extraction forms. Disagreements between the reviewers will be resolved by discussion, and if required, a third (senior) reviewer will arbitrate. The primary outcome is the prevalence of any standard features of diabetic retinopathy (DR) on fundus photography, as per International Clinical Diabetic Retinopathy Severity Scale (ICDRSS) classification. Secondary outcomes are the prevalence of (1) any retinal microvascular abnormalities on fundus photography that are not standard features of DR as per ICDRSS classification and (2) any macular microvascular abnormalities on fundus photography, including but not limited to the presence of macular exudates, microaneurysms and haemorrhages. Risk of bias for included studies will be assessed using a validated risk of bias tool for prevalence studies. Pooled estimates for the prespecified outcomes of interest will be calculated using random effects meta-analytic techniques. Heterogeneity will be assessed using the I(2) statistic. ETHICS AND DISSEMINATION: Ethical approval is not required as this is a protocol for a systematic review and no primary data are to be collected. Findings will be disseminated through peer-reviewed publications and presentations at national and international meetings including Diabetes UK, European Association for the Study of Diabetes, American Diabetes Association and International Diabetes Federation conferences. PROSPERO REGISTRATION NUMBER: CRD42020184820. |
format | Online Article Text |
id | pubmed-7797244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-77972442021-01-21 Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis Kirthi, Varo Nderitu, Paul Alam, Uazman Evans, Jennifer Nevitt, Sarah Malik, Rayaz A Jackson, Timothy L BMJ Open Diabetes and Endocrinology INTRODUCTION: There is growing evidence of a higher than expected prevalence of retinopathy in prediabetes. This paper presents the protocol of a systematic review and meta-analysis of retinopathy in prediabetes. The aim of the review is to estimate the prevalence of retinopathy in prediabetes and to summarise the current data. METHODS AND ANALYSIS: This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. A comprehensive electronic bibliographic search will be conducted in MEDLINE, EMBASE, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Google Scholar and the Cochrane Library. Eligible studies will report prevalence data for retinopathy on fundus photography in adults with prediabetes. No time restrictions will be placed on the date of publication. Screening for eligible studies and data extraction will be conducted by two reviewers independently, using predefined inclusion criteria and prepiloted data extraction forms. Disagreements between the reviewers will be resolved by discussion, and if required, a third (senior) reviewer will arbitrate. The primary outcome is the prevalence of any standard features of diabetic retinopathy (DR) on fundus photography, as per International Clinical Diabetic Retinopathy Severity Scale (ICDRSS) classification. Secondary outcomes are the prevalence of (1) any retinal microvascular abnormalities on fundus photography that are not standard features of DR as per ICDRSS classification and (2) any macular microvascular abnormalities on fundus photography, including but not limited to the presence of macular exudates, microaneurysms and haemorrhages. Risk of bias for included studies will be assessed using a validated risk of bias tool for prevalence studies. Pooled estimates for the prespecified outcomes of interest will be calculated using random effects meta-analytic techniques. Heterogeneity will be assessed using the I(2) statistic. ETHICS AND DISSEMINATION: Ethical approval is not required as this is a protocol for a systematic review and no primary data are to be collected. Findings will be disseminated through peer-reviewed publications and presentations at national and international meetings including Diabetes UK, European Association for the Study of Diabetes, American Diabetes Association and International Diabetes Federation conferences. PROSPERO REGISTRATION NUMBER: CRD42020184820. BMJ Publishing Group 2021-01-07 /pmc/articles/PMC7797244/ /pubmed/33414145 http://dx.doi.org/10.1136/bmjopen-2020-040997 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Diabetes and Endocrinology Kirthi, Varo Nderitu, Paul Alam, Uazman Evans, Jennifer Nevitt, Sarah Malik, Rayaz A Jackson, Timothy L Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis |
title | Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis |
title_full | Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis |
title_fullStr | Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis |
title_full_unstemmed | Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis |
title_short | Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis |
title_sort | prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis |
topic | Diabetes and Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797244/ https://www.ncbi.nlm.nih.gov/pubmed/33414145 http://dx.doi.org/10.1136/bmjopen-2020-040997 |
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