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Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes

Hepatitis B virus (HBV) mediates persistent infection, chronic hepatitis, and liver disease. HBV covalently closed circular (ccc)DNA is central to viral persistence such that its elimination is considered the cornerstone for HBV cure. Inefficient detection by pathogen recognition receptors (PRRs) in...

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Detalles Bibliográficos
Autores principales:	Lee, Sooyoung, Goyal, Ashish, Perelson, Alan S., Ishida, Yuji, Saito, Takeshi, Gale, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797372/ https://www.ncbi.nlm.nih.gov/pubmed/33458618 http://dx.doi.org/10.1016/j.isci.2020.101969

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