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Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1

BACKGROUND & AIMS: Aspirin reduces colorectal cancer (CRC) incidence and mortality. Understanding the biology responsible for this protective effect is key to developing biomarker-led approaches for rational clinical use. Wnt signaling drives CRC development from initiation to progression throug...

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Detalles Bibliográficos
Autores principales:	Dunbar, Karen, Valanciute, Asta, Lima, Ana Cristina Silva, Vinuela, Paz Freile, Jamieson, Thomas, Rajasekaran, Vidya, Blackmur, James, Ochocka-Fox, Anna-Maria, Guazzelli, Alice, Cammareri, Patrizia, Arends, Mark J., Sansom, Owen J., Myant, Kevin B., Farrington, Susan M., Dunlop, Malcolm G., Din, Farhat V.N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797380/ https://www.ncbi.nlm.nih.gov/pubmed/32971322 http://dx.doi.org/10.1016/j.jcmgh.2020.09.010

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