Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials

BACKGROUND: The HOX genes are master regulators of embryogenesis that are also involved in hematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles in hematopoiesis and leukemogenesis. METHODS: We established HOXA9-inducible human embryonic stem cells (HOXA9/hESCs)...

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Detalles Bibliográficos
Autores principales: Zeng, Jiahui, Yi, Danying, Sun, Wencui, Liu, Yuanlin, Chang, Jing, Zhu, Lijiao, Zhang, Yonggang, Pan, Xu, Dong, Yong, Zhou, Ya, Lai, Mowen, Bian, Guohui, Zhou, Qiongxiu, Liu, Jiaxin, Chen, Bo, Ma, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797385/
https://www.ncbi.nlm.nih.gov/pubmed/33426581
http://dx.doi.org/10.1186/s13619-020-00066-0

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