Cargando…

CDKN2A (p16(INK4A)) affects the anti-tumor effect of CDK inhibitor in somatotroph adenomas

The altered cell cycle is associated with aberrant growth factor signaling in somatotroph adenoma, which is the primary cause of acromegaly. The aim of the present study was to investigate the pathological role of the INK4 family and evaluate the effectiveness of CDK4 inhibitor, palbociclib, in soma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yiyuan, Li, Zhenye, Fang, Qiuyue, Wang, Hongyun, Li, Chuzhong, Gao, Hua, Zhang, Yazhuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797444/ https://www.ncbi.nlm.nih.gov/pubmed/33416096 http://dx.doi.org/10.3892/ijmm.2020.4807

Ejemplares similares

The Integrated Stress Response Is Tumorigenic and Constitutes a Therapeutic Liability in Somatotroph Adenomas
por: Li, Zhenye, et al.
Publicado: (2022)

Impact of SLC20A1 on the Wnt/β-catenin signaling pathway in somatotroph adenomas
por: Li, Jianhua, et al.
Publicado: (2019)

Identification of Serum miRNA-423-5p Expression Signature in Somatotroph Adenomas
por: Zhao, Sida, et al.
Publicado: (2019)

The effect of endoscopic transsphenoidal somatotroph tumors resection on pituitary hormones: systematic review and meta-analysis
por: Nie, Ding, et al.
Publicado: (2023)

Clinically silent somatotroph adenomas are common
por: Wade, Alisha N, et al.
Publicado: (2011)

Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas
por: Liu, Chunhui, et al.
Publicado: (2016)

Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy
por: Zhao, Sida, et al.
Publicado: (2023)

Change in the immunophenotype of a somatotroph adenoma resulting in gigantism
por: Thawani, Jayesh P., et al.
Publicado: (2014)

Thyrotropinoma with silent somatotroph and lactotroph adenoma during pregnancy
por: Wu, Yu-Fang, et al.
Publicado: (2022)

CCNB1 affects cavernous sinus invasion in pituitary adenomas through the epithelial–mesenchymal transition
por: Li, Bin, et al.
Publicado: (2019)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

Phosphorylation of kinase insert domain receptor by cyclin-dependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas
por: Xie, Weiyan, et al.
Publicado: (2016)

Pituitary Somatotroph Adenoma-derived Exosomes: Characterization of Nonhormonal Actions
por: Zhou, Cuiqi, et al.
Publicado: (2021)

Screening and Identification of Key Microenvironment-Related Genes in Non-functioning Pituitary Adenoma
por: Guo, Jing, et al.
Publicado: (2021)

JAG1, Regulated by microRNA-424-3p, Involved in Tumorigenesis and Epithelial–Mesenchymal Transition of High Proliferative Potential-Pituitary Adenomas
por: Chen, Yiyuan, et al.
Publicado: (2020)

Identifying critical protein-coding genes and long non-coding RNAs in non-functioning pituitary adenoma recurrence
por: Guo, Jing, et al.
Publicado: (2021)

Silencing of RASSF3 by DNA Hypermethylation Is Associated with Tumorigenesis in Somatotroph Adenomas
por: Peng, Hu, et al.
Publicado: (2013)

Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat
por: Alonso, Flavio H., et al.
Publicado: (2022)

Early Onset GH Excess: Somatotroph Adenoma in a Young Adult
por: Galbiati, Francesca, et al.
Publicado: (2023)

Research advances on the immune research and prospect of immunotherapy in pituitary adenomas
por: Nie, Ding, et al.
Publicado: (2021)

CDK5 and Its Activator P35 in Normal Pituitary and in Pituitary Adenomas: Relationship to VEGF Expression
por: Xie, Weiyan, et al.
Publicado: (2014)

Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas
por: Yao, Xiaohui, et al.
Publicado: (2019)

Quantitative Ubiquitinomics Revealed Abnormal Ubiquitinated ATP7A Involved in Down-Regulation of ACTH in Silent Corticotroph Adenomas
por: Zhao, Sida, et al.
Publicado: (2022)

Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data
por: Zhao, Peng, et al.
Publicado: (2015)

A Novel Three-LncRNA Signature Predicting Tumor Recurrence in Nonfunctioning Pituitary Adenomas
por: Cheng, Sen, et al.
Publicado: (2021)

Corrigendum to “Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data”
por: Zhao, Peng, et al.
Publicado: (2018)

The intestinal flora of patients with GHPA affects the growth and the expression of PD-L1 of tumor
por: Nie, Ding, et al.
Publicado: (2021)

Pituitary Somatotroph Adenoma Cell-Derived Exosomes: Characterization of Novel Non-Hormonal Functions
por: Zhou, Cuiqi, et al.
Publicado: (2021)

Silent Corticotroph and Somatotroph Double Pituitary Adenoma: A Case Report and Review of Literature
por: Pecorari, Isabella L., et al.
Publicado: (2022)

Genomic and transcriptomic analysis of pituitary adenomas reveals the impacts of copy number variations on gene expression and clinical prognosis among prolactin-secreting subtype
por: Chen, Yiyuan, et al.
Publicado: (2020)

LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis
por: Zhao, Peng, et al.
Publicado: (2021)

CDK6 and p16(INK4A) in lymphoid malignancies
por: Kollmann, Karoline, et al.
Publicado: (2013)

Genome-wide analysis of differentially expressed lncRNAs and mRNAs in primary gonadotrophin adenomas by RNA-seq
por: Li, Jiye, et al.
Publicado: (2016)

Early surgical intervention for patients with possible clinically silent somatotroph adenoma: a case series
por: Kawaguchi, Tomohiro, et al.
Publicado: (2019)

Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
por: Yamato, Azusa, et al.
Publicado: (2022)

ODP311 Giant-versus Macroadenomas: Does Size Really Matter in Pituitary Somatotroph Adenomas?
por: Sendur, Suleyman Nahit, et al.
Publicado: (2022)

Risk factors and management associated with postoperative cerebrospinal fluid leak after endoscopic endonasal surgery for pituitary adenoma
por: Li, Bin, et al.
Publicado: (2022)

The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1
por: Guo, Jing, et al.
Publicado: (2022)

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
por: Zhao, Ran, et al.
Publicado: (2016)

CDK6 Degradation Is Counteracted by p16(INK4A) and p18(INK4C) in AML
por: Schmalzbauer, Belinda S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7l75rvr79lcf2v8mr5kvu6d9ga