COVID-19: Analysis of Drug Repositioning Practice

An outbreak of a new coronavirus disease (COVID-19) in China in December 2019 became the epicenter for the spread of a global pandemic. The SARS-CoV-2 coronavirus causes a cascade of respiratory diseases similar to severe acute respiratory syndrome (SARS). Currently, there is no effective, specific,...

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Detalles Bibliográficos
Autores principales: Savosina, P. I., Druzhilovskii, D. S., Poroikov, V. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Search for New Drugs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797491/
https://www.ncbi.nlm.nih.gov/pubmed/33456092
http://dx.doi.org/10.1007/s11094-021-02308-0
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author Savosina, P. I.
Druzhilovskii, D. S.
Poroikov, V. V.
author_facet Savosina, P. I.
Druzhilovskii, D. S.
Poroikov, V. V.
author_sort Savosina, P. I.
collection PubMed
description An outbreak of a new coronavirus disease (COVID-19) in China in December 2019 became the epicenter for the spread of a global pandemic. The SARS-CoV-2 coronavirus causes a cascade of respiratory diseases similar to severe acute respiratory syndrome (SARS). Currently, there is no effective, specific, and safe treatment for COVID-19 to suppress the virus in the human body. The present study searched for pharmacological substances with antiviral activity for possible drug repositioning based on experimental and theoretical information in a series of publications on in vitro assays of agents against SARS-CoV-2. An analysis identified 46 well-known pharmaceutical substances that could be used for drug repositioning to create a therapy for COVID-19.
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spelling pubmed-77974912021-01-11 COVID-19: Analysis of Drug Repositioning Practice Savosina, P. I. Druzhilovskii, D. S. Poroikov, V. V. Pharm Chem J Search for New Drugs An outbreak of a new coronavirus disease (COVID-19) in China in December 2019 became the epicenter for the spread of a global pandemic. The SARS-CoV-2 coronavirus causes a cascade of respiratory diseases similar to severe acute respiratory syndrome (SARS). Currently, there is no effective, specific, and safe treatment for COVID-19 to suppress the virus in the human body. The present study searched for pharmacological substances with antiviral activity for possible drug repositioning based on experimental and theoretical information in a series of publications on in vitro assays of agents against SARS-CoV-2. An analysis identified 46 well-known pharmaceutical substances that could be used for drug repositioning to create a therapy for COVID-19. Springer US 2021-01-11 2021 /pmc/articles/PMC7797491/ /pubmed/33456092 http://dx.doi.org/10.1007/s11094-021-02308-0 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Search for New Drugs
Savosina, P. I.
Druzhilovskii, D. S.
Poroikov, V. V.
COVID-19: Analysis of Drug Repositioning Practice
title COVID-19: Analysis of Drug Repositioning Practice
title_full COVID-19: Analysis of Drug Repositioning Practice
title_fullStr COVID-19: Analysis of Drug Repositioning Practice
title_full_unstemmed COVID-19: Analysis of Drug Repositioning Practice
title_short COVID-19: Analysis of Drug Repositioning Practice
title_sort covid-19: analysis of drug repositioning practice
topic Search for New Drugs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797491/
https://www.ncbi.nlm.nih.gov/pubmed/33456092
http://dx.doi.org/10.1007/s11094-021-02308-0
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