Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19

COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activ...

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Detalles Bibliográficos
Autores principales: Li, Dingzhong, Hu, Jianbing, Li, Dian, Yang, Weijun, Yin, Shuang-Feng, Qiu, Renhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797499/
https://www.ncbi.nlm.nih.gov/pubmed/33428032
http://dx.doi.org/10.1007/s41061-020-00318-2
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author Li, Dingzhong
Hu, Jianbing
Li, Dian
Yang, Weijun
Yin, Shuang-Feng
Qiu, Renhua
author_facet Li, Dingzhong
Hu, Jianbing
Li, Dian
Yang, Weijun
Yin, Shuang-Feng
Qiu, Renhua
author_sort Li, Dingzhong
collection PubMed
description COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activity, including antiviral drugs, antimalarial drugs, immunosuppressants, Chinese medicines, M(pro) inhibitors, JAK inhibitors, etc. The most commonly used drugs are antiviral compounds, antimalarial drugs and JAK inhibitors. In this review, we summarize mainly the antimalarial drugs chloroquine and hydroxychloroquine, the antiviral drugs Favipiravir and Remdesivir, and JAK inhibitor Ruxolitinib, discussing their biological activities, clinical trials and synthesis progress.
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spelling pubmed-77974992021-01-11 Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19 Li, Dingzhong Hu, Jianbing Li, Dian Yang, Weijun Yin, Shuang-Feng Qiu, Renhua Top Curr Chem (Cham) Review COVID-19 has broken out rapidly in nearly all countries worldwide, and has blossomed into a pandemic. Since the beginning of the spread of COVID-19, many scientists have been cooperating to study a vast array of old drugs and new clinical trial drugs to discover potent drugs with anti-COVID-19 activity, including antiviral drugs, antimalarial drugs, immunosuppressants, Chinese medicines, M(pro) inhibitors, JAK inhibitors, etc. The most commonly used drugs are antiviral compounds, antimalarial drugs and JAK inhibitors. In this review, we summarize mainly the antimalarial drugs chloroquine and hydroxychloroquine, the antiviral drugs Favipiravir and Remdesivir, and JAK inhibitor Ruxolitinib, discussing their biological activities, clinical trials and synthesis progress. Springer International Publishing 2021-01-11 2021 /pmc/articles/PMC7797499/ /pubmed/33428032 http://dx.doi.org/10.1007/s41061-020-00318-2 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Li, Dingzhong
Hu, Jianbing
Li, Dian
Yang, Weijun
Yin, Shuang-Feng
Qiu, Renhua
Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
title Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
title_full Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
title_fullStr Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
title_full_unstemmed Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
title_short Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
title_sort reviews on biological activity, clinical trial and synthesis progress of small molecules for the treatment of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797499/
https://www.ncbi.nlm.nih.gov/pubmed/33428032
http://dx.doi.org/10.1007/s41061-020-00318-2
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