Cargando…

Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2 and MMP-9 via the AMPK/SIRT1 pathway in non-small cell lung cancer

Salinomycin (Sal) is a recently identified anti-tumor drug for treating several types of solid tumor; however, its effects on the migratory and invasive properties of non-small cell lung cancer (NSCLC) remain unclear. This study investigated the inhibitory effect underlying mechanisms of Salon trans...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwang, Ki-Eun, Kim, Hyo-Jin, Song, In-Sol, Park, Chul, Jung, Jae Wan, Park, Do-Sim, Oh, Seon-Hee, Kim, Young-Suk, Kim, Hak-Ryul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797542/ https://www.ncbi.nlm.nih.gov/pubmed/33437206 http://dx.doi.org/10.7150/ijms.50080

Ejemplares similares

Inhibition of MMP1, MMP2 and MMP8 by mepacrine
por: Pollaschek, C, et al.
Publicado: (2003)

Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast
por: Kim, Hee Jung, et al.
Publicado: (2006)

NOGO-B promotes EMT in lung fibrosis via MMP14 mediates free TGF-beta1 formation
por: Xiong, Ye, et al.
Publicado: (2017)

TIMP-1 Induces an EMT-Like Phenotypic Conversion in MDCK Cells Independent of Its MMP-Inhibitory Domain
por: Jung, Young Suk, et al.
Publicado: (2012)

MMP-1, MMP-3 and MMP-10 are involved in the degradation of cartilage
por: Tolboom, TCA, et al.
Publicado: (2001)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
por: Meneses-García, Abelardo, et al.
Publicado: (2008)

Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury
por: Kim, Jooyoung, et al.
Publicado: (2020)

Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
por: Son, Hyeong-U, et al.
Publicado: (2021)

MT2-MMP induces proteolysis and leads to EMT in carcinomas
por: Liu, Yusi, et al.
Publicado: (2016)

Paracrine regulation of neural crest EMT by placodal MMP28
por: Gouignard, Nadège, et al.
Publicado: (2023)

Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta
por: Kuźnik-Trocha, Kornelia, et al.
Publicado: (2020)

TGF-β1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells
por: Yamahana, Hirari, et al.
Publicado: (2021)

The Protein Extract of Chlorella minutissima Inhibits The Expression of MMP-1, MMP-2 and MMP-9 in Cancer Cells through Upregulation of TIMP-3 and Down Regulation of c-Jun
por: Kunte, Mugdha, et al.
Publicado: (2018)

Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
por: Nosratzehi, Tahereh, et al.
Publicado: (2017)

Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
por: Sakowicz, Agata, et al.
Publicado: (2018)

Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma
por: Lièvre, Astrid, et al.
Publicado: (2006)

Activation of MMP‐9 by membrane type‐1 MMP/MMP‐2 axis stimulates tumor metastasis
por: Li, Zichen, et al.
Publicado: (2017)

Gold Nanoparticles Using Ecklonia stolonifera Protect Human Dermal Fibroblasts from UVA-Induced Senescence through Inhibiting MMP-1 and MMP-3
por: Jun, Eun-Sook, et al.
Publicado: (2020)

Plasma MMP1, MMP8 and MMP13 expression in breast cancer: protective role of MMP8 against lymph node metastasis
por: Decock, J, et al.
Publicado: (2008)

The in vitro anti-fibrotic effect of Pirfenidone on human pterygium fibroblasts is associated with down-regulation of autocrine TGF-β and MMP-1
por: Tao, Yijin, et al.
Publicado: (2020)

MMP9 Differentially Regulates Proteins Involved in Actin Polymerization and Cell Migration during TGF-β-Induced EMT in the Lens
por: Liu, Zi Zhen (Ginny), et al.
Publicado: (2021)

Salinomycin inhibits hepatocellular carcinoma cell invasion and migration through JNK/JunD pathway-mediated MMP9 expression
por: XU, LING, et al.
Publicado: (2015)

Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas
por: Mossböck, Georg, et al.
Publicado: (2010)

The MMP-1, MMP-2, and MMP-9 gene polymorphisms and susceptibility to bladder cancer: a meta-analysis
por: Yan, Yulan, et al.
Publicado: (2014)

Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events
por: Hu, Wei, et al.
Publicado: (2018)

The immunoexpression of MMP-1 and MMP-13 in eyelid basal cell carcinoma
por: Mercuţ, Irina-Maria, et al.
Publicado: (2020)

Pro-apoptotic and migration-suppressing potential of EGCG, and the involvement of AMPK in the p53-mediated modulation of VEGF and MMP-9 expression
por: PARK, SONG YI, et al.
Publicado: (2013)

Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer
por: Padala, Chiranjeevi, et al.
Publicado: (2017)

Managing MMP-2, MMP-9, VEGFR-2, TGFβ-1, and TIMP-1 in NNK-induced lung carcinoma by nonchemical interventions in female rats
por: Abrishami Kia, Zahra, et al.
Publicado: (2022)

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells
por: Endo, Hitoshi, et al.
Publicado: (2018)

Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers
por: Kerkelä, E, et al.
Publicado: (2001)

Hematopoietic Stem Cell Mobilization and Homing after Transplantation: The Role of MMP-2, MMP-9, and MT1-MMP
por: Shirvaikar, Neeta, et al.
Publicado: (2012)

Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
por: Mori, Sachiko, et al.
Publicado: (2012)

Associations of MMP1, MMP2 and MMP3 Genes Polymorphism with Coal Workers’ Pneumoconiosis in Chinese Han Population
por: Ji, Xiaoming, et al.
Publicado: (2015)

Effect of Kaempferol on the Biological Behavior of Human Colon Cancer via Regulating MMP1, MMP2, and MMP9
por: Zhang, Xiaoyu, et al.
Publicado: (2022)

133 Corticosteroid Rreatment Reduces Tissue Eosinophilia and the Expression of Matrix Metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9) and Their Tissue Inhibitor (TIMP-1) in Nasal Polyps
por: de Borja Callejas, Fco, et al.
Publicado: (2012)

MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer
por: Vos, Maria Caroline, et al.
Publicado: (2016)

Inhibition of MMP-2 and MMP-9 Activities by Limonium tetragonum Extract
por: Bae, Min-Joo, et al.
Publicado: (2016)

Combination of ACY-241 and JQ1 Synergistically Suppresses Metastasis of HNSCC via Regulation of MMP-2 and MMP-9
por: Cho, Ha Young, et al.
Publicado: (2020)

The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse
por: Skorupski, Paweł, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_fh24fhevdhnhhsnhv5a4j61mp0