Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer

Rationale: Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass. Type I collagen is the major component of the extracellular matrix (ECM), which acts as a barrier to impede the delivery of drugs into the tumor...

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Detalles Bibliográficos
Autores principales: Li, Yuanke, Zhao, Zhen, Lin, Chien-Yu, Liu, Yanli, Staveley-OCarroll, Kevin F., Li, Guangfu, Cheng, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797682/
https://www.ncbi.nlm.nih.gov/pubmed/33500719
http://dx.doi.org/10.7150/thno.53102

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