Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial

BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. METHODS: We conducted a single-arm, open-label,...

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Detalles Bibliográficos
Autores principales: Kakimoto, Kazuki, Matsuura, Minoru, Fukuchi, Takumi, Hongo, Hitoshi, Kimura, Tsuguhiro, Aoyama, Nobuo, Okuda, Yorihide, Aomatsu, Kazuki, Kamata, Noriko, Yokoyama, Yoko, Mizuno, Chiemi, Inoue, Takuya, Miyazaki, Takako, Nakamura, Shiro, Higuchi, Kazuhide, Nakase, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797742/
https://www.ncbi.nlm.nih.gov/pubmed/34192247
http://dx.doi.org/10.1093/crocol/otaa073
Descripción
Sumario:BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. METHODS: We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks. RESULTS: The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing. CONCLUSIONS: GMA shows effectiveness in inducing remission in UC patients not receiving steroid.

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