Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial

BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. METHODS: We conducted a single-arm, open-label,...

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Autores principales: Kakimoto, Kazuki, Matsuura, Minoru, Fukuchi, Takumi, Hongo, Hitoshi, Kimura, Tsuguhiro, Aoyama, Nobuo, Okuda, Yorihide, Aomatsu, Kazuki, Kamata, Noriko, Yokoyama, Yoko, Mizuno, Chiemi, Inoue, Takuya, Miyazaki, Takako, Nakamura, Shiro, Higuchi, Kazuhide, Nakase, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797742/
https://www.ncbi.nlm.nih.gov/pubmed/34192247
http://dx.doi.org/10.1093/crocol/otaa073
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author Kakimoto, Kazuki
Matsuura, Minoru
Fukuchi, Takumi
Hongo, Hitoshi
Kimura, Tsuguhiro
Aoyama, Nobuo
Okuda, Yorihide
Aomatsu, Kazuki
Kamata, Noriko
Yokoyama, Yoko
Mizuno, Chiemi
Inoue, Takuya
Miyazaki, Takako
Nakamura, Shiro
Higuchi, Kazuhide
Nakase, Hiroshi
author_facet Kakimoto, Kazuki
Matsuura, Minoru
Fukuchi, Takumi
Hongo, Hitoshi
Kimura, Tsuguhiro
Aoyama, Nobuo
Okuda, Yorihide
Aomatsu, Kazuki
Kamata, Noriko
Yokoyama, Yoko
Mizuno, Chiemi
Inoue, Takuya
Miyazaki, Takako
Nakamura, Shiro
Higuchi, Kazuhide
Nakase, Hiroshi
author_sort Kakimoto, Kazuki
collection PubMed
description BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. METHODS: We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks. RESULTS: The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing. CONCLUSIONS: GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
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spelling pubmed-77977422021-01-12 Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial Kakimoto, Kazuki Matsuura, Minoru Fukuchi, Takumi Hongo, Hitoshi Kimura, Tsuguhiro Aoyama, Nobuo Okuda, Yorihide Aomatsu, Kazuki Kamata, Noriko Yokoyama, Yoko Mizuno, Chiemi Inoue, Takuya Miyazaki, Takako Nakamura, Shiro Higuchi, Kazuhide Nakase, Hiroshi Crohns Colitis 360 Observations and Research BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. METHODS: We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks. RESULTS: The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing. CONCLUSIONS: GMA shows effectiveness in inducing remission in UC patients not receiving steroid. Oxford University Press 2020-09-23 /pmc/articles/PMC7797742/ /pubmed/34192247 http://dx.doi.org/10.1093/crocol/otaa073 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Observations and Research
Kakimoto, Kazuki
Matsuura, Minoru
Fukuchi, Takumi
Hongo, Hitoshi
Kimura, Tsuguhiro
Aoyama, Nobuo
Okuda, Yorihide
Aomatsu, Kazuki
Kamata, Noriko
Yokoyama, Yoko
Mizuno, Chiemi
Inoue, Takuya
Miyazaki, Takako
Nakamura, Shiro
Higuchi, Kazuhide
Nakase, Hiroshi
Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial
title Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial
title_full Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial
title_fullStr Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial
title_full_unstemmed Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial
title_short Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial
title_sort exploratory study of the effectiveness of granulocyte and monocyte adsorptive apheresis before initiation of steroids in patients with active ulcerative colitis (expect study): a multicenter prospective clinical trial
topic Observations and Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797742/
https://www.ncbi.nlm.nih.gov/pubmed/34192247
http://dx.doi.org/10.1093/crocol/otaa073
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