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Chronic lymphocytic leukemia B-cell-derived TNFα impairs bone marrow myelopoiesis

TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture of CLL B cells with purified normal human hematopoietic stem...

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Detalles Bibliográficos
Autores principales:	Manso, Bryce A., Krull, Jordan E., Gwin, Kimberly A., Lothert, Petra K., Welch, Baustin M., Novak, Anne J., Parikh, Sameer A., Kay, Neil E., Medina, Kay L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797930/ https://www.ncbi.nlm.nih.gov/pubmed/33458625 http://dx.doi.org/10.1016/j.isci.2020.101994

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