Association between B-Myb proto-oncogene and the development of malignant tumors

B-Myb is a critical transcription factor in regulating cell cycle. Dysregulated expression of B-Myb promotes tumor formation and development. B-Myb is a proto-oncogene ubiquitously expressed in proliferating cells, which maintains normal cell cycle progression. It participates in cell apoptosis, tum...

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Autores principales: Jin, Yuelei, Qi, Gangqiao, Chen, Guang, Wang, Chen, Fan, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798104/
https://www.ncbi.nlm.nih.gov/pubmed/33552284
http://dx.doi.org/10.3892/ol.2021.12427
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author Jin, Yuelei
Qi, Gangqiao
Chen, Guang
Wang, Chen
Fan, Xiaoyan
author_facet Jin, Yuelei
Qi, Gangqiao
Chen, Guang
Wang, Chen
Fan, Xiaoyan
author_sort Jin, Yuelei
collection PubMed
description B-Myb is a critical transcription factor in regulating cell cycle. Dysregulated expression of B-Myb promotes tumor formation and development. B-Myb is a proto-oncogene ubiquitously expressed in proliferating cells, which maintains normal cell cycle progression. It participates in cell apoptosis, tumorigenesis and aging. In addition, B-Myb is overexpressed in several malignant tumors, including breast cancer, lung cancer and hepatocellular carcinoma, and is associated with tumor development. B-Myb expression is also associated with the prognosis of patients with malignant tumors. Both microRNAs and E2F family of transcription factors (E2Fs) contribute to the function of B-Myb. The present review highlights the association between B-Myb and malignant tumors, and offers a theoretical reference for the diagnosis and treatment of malignant tumors.
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spelling pubmed-77981042021-02-04 Association between B-Myb proto-oncogene and the development of malignant tumors Jin, Yuelei Qi, Gangqiao Chen, Guang Wang, Chen Fan, Xiaoyan Oncol Lett Review B-Myb is a critical transcription factor in regulating cell cycle. Dysregulated expression of B-Myb promotes tumor formation and development. B-Myb is a proto-oncogene ubiquitously expressed in proliferating cells, which maintains normal cell cycle progression. It participates in cell apoptosis, tumorigenesis and aging. In addition, B-Myb is overexpressed in several malignant tumors, including breast cancer, lung cancer and hepatocellular carcinoma, and is associated with tumor development. B-Myb expression is also associated with the prognosis of patients with malignant tumors. Both microRNAs and E2F family of transcription factors (E2Fs) contribute to the function of B-Myb. The present review highlights the association between B-Myb and malignant tumors, and offers a theoretical reference for the diagnosis and treatment of malignant tumors. D.A. Spandidos 2021-02 2021-01-04 /pmc/articles/PMC7798104/ /pubmed/33552284 http://dx.doi.org/10.3892/ol.2021.12427 Text en Copyright: © Jin et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Jin, Yuelei
Qi, Gangqiao
Chen, Guang
Wang, Chen
Fan, Xiaoyan
Association between B-Myb proto-oncogene and the development of malignant tumors
title Association between B-Myb proto-oncogene and the development of malignant tumors
title_full Association between B-Myb proto-oncogene and the development of malignant tumors
title_fullStr Association between B-Myb proto-oncogene and the development of malignant tumors
title_full_unstemmed Association between B-Myb proto-oncogene and the development of malignant tumors
title_short Association between B-Myb proto-oncogene and the development of malignant tumors
title_sort association between b-myb proto-oncogene and the development of malignant tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798104/
https://www.ncbi.nlm.nih.gov/pubmed/33552284
http://dx.doi.org/10.3892/ol.2021.12427
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