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MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer

Pancreatic cancer (PC) is a common malignant disease worldwide. Among the potential pathogenic factors, Helicobacter pylori (H. pylori) infection has been associated with the tumorigenesis of PC. The present study aimed to identify the differentially expressed genes (DEGs) of H. pylori infection-ass...

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Autores principales: Gong, Yu, Chen, Shuai, Fu, Yue, Liu, Yu, Wang, Yipeng, Yang, Haojun, Liu, Hanyang, Tang, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798107/
https://www.ncbi.nlm.nih.gov/pubmed/33552244
http://dx.doi.org/10.3892/ol.2020.12384
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author Gong, Yu
Chen, Shuai
Fu, Yue
Liu, Yu
Wang, Yipeng
Yang, Haojun
Liu, Hanyang
Tang, Liming
author_facet Gong, Yu
Chen, Shuai
Fu, Yue
Liu, Yu
Wang, Yipeng
Yang, Haojun
Liu, Hanyang
Tang, Liming
author_sort Gong, Yu
collection PubMed
description Pancreatic cancer (PC) is a common malignant disease worldwide. Among the potential pathogenic factors, Helicobacter pylori (H. pylori) infection has been associated with the tumorigenesis of PC. The present study aimed to identify the differentially expressed genes (DEGs) of H. pylori infection-associated PC and to investigate the key factors involved in PC tumorigenesis. Using bioinformatics methods, overlapping DEGs and key gene were identified from H. pylori-infected gastric mucosa (GM) and H. pylori infection-associated PC. Survival and tumor stage analyses were performed to assess the clinical associations. In addition, mucin 4 (MUC4) mRNA expression levels were measured in patient blood and tumor samples. According to the correlation analyses of four genes co-expressed, potential biological processes were identified. MUC4 was identified to be associated with H. pylori infection, and its levels were significantly upregulated in PC samples compared with those in normal samples in TCGA dataset, the PC cell line and patient tissue samples. H. pylori infection was also associated with MUC4 expression in patients' blood and tissue samples. In conclusion, the results of the present study revealed a potentially pathogenic role of MUC4 in H. pylori infection-associated PC. Thus, the tumorigenesis and metastasis of PC may be prevented by treating the H. pylori infection or using MUC4 antagonists.
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spelling pubmed-77981072021-02-04 MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer Gong, Yu Chen, Shuai Fu, Yue Liu, Yu Wang, Yipeng Yang, Haojun Liu, Hanyang Tang, Liming Oncol Lett Articles Pancreatic cancer (PC) is a common malignant disease worldwide. Among the potential pathogenic factors, Helicobacter pylori (H. pylori) infection has been associated with the tumorigenesis of PC. The present study aimed to identify the differentially expressed genes (DEGs) of H. pylori infection-associated PC and to investigate the key factors involved in PC tumorigenesis. Using bioinformatics methods, overlapping DEGs and key gene were identified from H. pylori-infected gastric mucosa (GM) and H. pylori infection-associated PC. Survival and tumor stage analyses were performed to assess the clinical associations. In addition, mucin 4 (MUC4) mRNA expression levels were measured in patient blood and tumor samples. According to the correlation analyses of four genes co-expressed, potential biological processes were identified. MUC4 was identified to be associated with H. pylori infection, and its levels were significantly upregulated in PC samples compared with those in normal samples in TCGA dataset, the PC cell line and patient tissue samples. H. pylori infection was also associated with MUC4 expression in patients' blood and tissue samples. In conclusion, the results of the present study revealed a potentially pathogenic role of MUC4 in H. pylori infection-associated PC. Thus, the tumorigenesis and metastasis of PC may be prevented by treating the H. pylori infection or using MUC4 antagonists. D.A. Spandidos 2021-02 2020-12-17 /pmc/articles/PMC7798107/ /pubmed/33552244 http://dx.doi.org/10.3892/ol.2020.12384 Text en Copyright: © Gong et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Gong, Yu
Chen, Shuai
Fu, Yue
Liu, Yu
Wang, Yipeng
Yang, Haojun
Liu, Hanyang
Tang, Liming
MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer
title MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer
title_full MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer
title_fullStr MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer
title_full_unstemmed MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer
title_short MUC4 is a novel mediator in H. pylori infection-related pancreatic cancer
title_sort muc4 is a novel mediator in h. pylori infection-related pancreatic cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798107/
https://www.ncbi.nlm.nih.gov/pubmed/33552244
http://dx.doi.org/10.3892/ol.2020.12384
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