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Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains

BACKGROUND: To identify site-specific features of amino acid substitutions that confer enhanced H7N9 virulence in humans, we independently generated mammalian-adapted variants of A/Anhui/1/2013 (AH-H7N9) and A/Shanghai/2/2013 (SH-H7N9) by serial passaging in Madin-Darby canine kidney (MDCK) cells. M...

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Detalles Bibliográficos
Autores principales:	Zhang, Ting, Du, Haiwei, Guo, Li, Liu, Feng, Su, Haoxiang, Yang, Fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798331/ https://www.ncbi.nlm.nih.gov/pubmed/33430903 http://dx.doi.org/10.1186/s12985-020-01464-1

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