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Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial

INTRODUCTION: The literature shows that selective carious tissue removal (SCTR) decreases the number and diversity of bacteria, stops the caries process and reduces the risk of pulp exposure. However, no consensus exists on which pulp liner would be suitable for teeth undergoing SCTR. So, this study...

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Autores principales: Stafuzza, Tássia Carina, Vitor, Luciana Lourenço Ribeiro, Lourenço Neto, Natalino, Rios, Daniela, Cruvinel, Thiago, Sakai, Vivien Thiemy, Moretti, Ana Beatriz Silveira, Machado, Maria Aparecida Andrade Moreira, Oliveira, Thais Marchini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798680/
https://www.ncbi.nlm.nih.gov/pubmed/33419899
http://dx.doi.org/10.1136/bmjopen-2019-029612
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author Stafuzza, Tássia Carina
Vitor, Luciana Lourenço Ribeiro
Lourenço Neto, Natalino
Rios, Daniela
Cruvinel, Thiago
Sakai, Vivien Thiemy
Moretti, Ana Beatriz Silveira
Machado, Maria Aparecida Andrade Moreira
Oliveira, Thais Marchini
author_facet Stafuzza, Tássia Carina
Vitor, Luciana Lourenço Ribeiro
Lourenço Neto, Natalino
Rios, Daniela
Cruvinel, Thiago
Sakai, Vivien Thiemy
Moretti, Ana Beatriz Silveira
Machado, Maria Aparecida Andrade Moreira
Oliveira, Thais Marchini
author_sort Stafuzza, Tássia Carina
collection PubMed
description INTRODUCTION: The literature shows that selective carious tissue removal (SCTR) decreases the number and diversity of bacteria, stops the caries process and reduces the risk of pulp exposure. However, no consensus exists on which pulp liner would be suitable for teeth undergoing SCTR. So, this study will verify the in vivo response of dentine–pulp complex after SCTR in primary teeth with or without pulp liner material. METHODS AND ANALYSIS: A randomised clinical trial, double-blinded, parallel-group and allocation concealment will be conducted with the enrolment of 384 patients from 5 to 9 years, with one maxillary/mandibular first/second primary molars with deep occlusal/occlusoproximal cavities. The remaining dentine will be lined with calcium hydroxide cement—group 1; mineral trioxide aggregate—group 2 and without liner—group 3. The primary outcome will be success of the of dentine–pulp complex evaluated clinically and radiographically at 6, 12 and 24 months, while the secondary outcomes will be the measurement of the dentine barrier on periapical radiographs. During all study, two trained and calibrated examiners will evaluate the treated teeth clinically and radiographically. Interexaminer and intraexaminer reliability will be verified by casual and systematic error. The Kolmogorov–Smirnov test will be adopted to test the normality of continuous variables. Comparisons among groups will be performed by using the χ(2) test and anaylsis of variance, followed by Tukey test (p<0.05). The logistic regression will be applied, and the degrees of this association will be measured using the OR and 95% CI. ETHICS AND DISSEMINATION: The present protocol was submitted and approved by the Ethical Committee of the University of São Paulo, Bauru, São Paulo, Brazil (CAAE: 79123517.0.0000.5417). Consent for publication will be obtained from all parents or legal guardians. Results of this study will be reported in full through peer-reviewed journals. TRIAL REGISTRATION NUMBER: RBR-9fsxnn.
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spelling pubmed-77986802021-01-21 Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial Stafuzza, Tássia Carina Vitor, Luciana Lourenço Ribeiro Lourenço Neto, Natalino Rios, Daniela Cruvinel, Thiago Sakai, Vivien Thiemy Moretti, Ana Beatriz Silveira Machado, Maria Aparecida Andrade Moreira Oliveira, Thais Marchini BMJ Open Dentistry and Oral Medicine INTRODUCTION: The literature shows that selective carious tissue removal (SCTR) decreases the number and diversity of bacteria, stops the caries process and reduces the risk of pulp exposure. However, no consensus exists on which pulp liner would be suitable for teeth undergoing SCTR. So, this study will verify the in vivo response of dentine–pulp complex after SCTR in primary teeth with or without pulp liner material. METHODS AND ANALYSIS: A randomised clinical trial, double-blinded, parallel-group and allocation concealment will be conducted with the enrolment of 384 patients from 5 to 9 years, with one maxillary/mandibular first/second primary molars with deep occlusal/occlusoproximal cavities. The remaining dentine will be lined with calcium hydroxide cement—group 1; mineral trioxide aggregate—group 2 and without liner—group 3. The primary outcome will be success of the of dentine–pulp complex evaluated clinically and radiographically at 6, 12 and 24 months, while the secondary outcomes will be the measurement of the dentine barrier on periapical radiographs. During all study, two trained and calibrated examiners will evaluate the treated teeth clinically and radiographically. Interexaminer and intraexaminer reliability will be verified by casual and systematic error. The Kolmogorov–Smirnov test will be adopted to test the normality of continuous variables. Comparisons among groups will be performed by using the χ(2) test and anaylsis of variance, followed by Tukey test (p<0.05). The logistic regression will be applied, and the degrees of this association will be measured using the OR and 95% CI. ETHICS AND DISSEMINATION: The present protocol was submitted and approved by the Ethical Committee of the University of São Paulo, Bauru, São Paulo, Brazil (CAAE: 79123517.0.0000.5417). Consent for publication will be obtained from all parents or legal guardians. Results of this study will be reported in full through peer-reviewed journals. TRIAL REGISTRATION NUMBER: RBR-9fsxnn. BMJ Publishing Group 2021-01-08 /pmc/articles/PMC7798680/ /pubmed/33419899 http://dx.doi.org/10.1136/bmjopen-2019-029612 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Dentistry and Oral Medicine
Stafuzza, Tássia Carina
Vitor, Luciana Lourenço Ribeiro
Lourenço Neto, Natalino
Rios, Daniela
Cruvinel, Thiago
Sakai, Vivien Thiemy
Moretti, Ana Beatriz Silveira
Machado, Maria Aparecida Andrade Moreira
Oliveira, Thais Marchini
Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial
title Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial
title_full Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial
title_fullStr Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial
title_full_unstemmed Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial
title_short Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial
title_sort pulp liner materials in selective caries removal: study protocol for a randomised controlled trial
topic Dentistry and Oral Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798680/
https://www.ncbi.nlm.nih.gov/pubmed/33419899
http://dx.doi.org/10.1136/bmjopen-2019-029612
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