Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020

We report off-label use patterns for medications repurposed for coronavirus disease 2019 (COVID-19) at 318 US hospitals. Inpatient hydroxychloroquine use declined by 80%, whereas corticosteroids and tocilizumab were initiated 2 days earlier in May versus March 2020. Two thirds of ventilated COVID-19...

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Detalles Bibliográficos
Autores principales: Kadri, Sameer S, Demirkale, Cumhur Y, Sun, Junfeng, Busch, Lindsay M, Strich, Jeffrey R, Rosenthal, Ning, Warner, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798707/
https://www.ncbi.nlm.nih.gov/pubmed/33556157
http://dx.doi.org/10.1093/ofid/ofaa616
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author Kadri, Sameer S
Demirkale, Cumhur Y
Sun, Junfeng
Busch, Lindsay M
Strich, Jeffrey R
Rosenthal, Ning
Warner, Sarah
author_facet Kadri, Sameer S
Demirkale, Cumhur Y
Sun, Junfeng
Busch, Lindsay M
Strich, Jeffrey R
Rosenthal, Ning
Warner, Sarah
author_sort Kadri, Sameer S
collection PubMed
description We report off-label use patterns for medications repurposed for coronavirus disease 2019 (COVID-19) at 318 US hospitals. Inpatient hydroxychloroquine use declined by 80%, whereas corticosteroids and tocilizumab were initiated 2 days earlier in May versus March 2020. Two thirds of ventilated COVID-19 patients were already receiving corticosteroids during March–May 2020, resembling pre-COVID use in mechanically ventilated influenza patients.
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spelling pubmed-77987072021-01-25 Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020 Kadri, Sameer S Demirkale, Cumhur Y Sun, Junfeng Busch, Lindsay M Strich, Jeffrey R Rosenthal, Ning Warner, Sarah Open Forum Infect Dis Brief Reports We report off-label use patterns for medications repurposed for coronavirus disease 2019 (COVID-19) at 318 US hospitals. Inpatient hydroxychloroquine use declined by 80%, whereas corticosteroids and tocilizumab were initiated 2 days earlier in May versus March 2020. Two thirds of ventilated COVID-19 patients were already receiving corticosteroids during March–May 2020, resembling pre-COVID use in mechanically ventilated influenza patients. Oxford University Press 2020-12-15 /pmc/articles/PMC7798707/ /pubmed/33556157 http://dx.doi.org/10.1093/ofid/ofaa616 Text en Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Brief Reports
Kadri, Sameer S
Demirkale, Cumhur Y
Sun, Junfeng
Busch, Lindsay M
Strich, Jeffrey R
Rosenthal, Ning
Warner, Sarah
Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020
title Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020
title_full Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020
title_fullStr Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020
title_full_unstemmed Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020
title_short Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March–May 2020
title_sort real-world inpatient use of medications repurposed for coronavirus disease 2019 in united states hospitals, march–may 2020
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798707/
https://www.ncbi.nlm.nih.gov/pubmed/33556157
http://dx.doi.org/10.1093/ofid/ofaa616
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