Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n  =  455 patients), severe acute respiratory syndrome ([SARS] n  =  ...

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Autores principales: Dolby, Heather W, Potey, Philippe, Wilder-Smith, Annika B, Clohisey, Sara, Millar, Jonathan E, Baillie, J Kenneth, Dorward, David A, Lucas, Christopher D, Russell, Clark D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798721/
https://www.ncbi.nlm.nih.gov/pubmed/33553478
http://dx.doi.org/10.1093/ofid/ofaa640
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author Dolby, Heather W
Potey, Philippe
Wilder-Smith, Annika B
Clohisey, Sara
Millar, Jonathan E
Baillie, J Kenneth
Dorward, David A
Lucas, Christopher D
Russell, Clark D
author_facet Dolby, Heather W
Potey, Philippe
Wilder-Smith, Annika B
Clohisey, Sara
Millar, Jonathan E
Baillie, J Kenneth
Dorward, David A
Lucas, Christopher D
Russell, Clark D
author_sort Dolby, Heather W
collection PubMed
description Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n  =  455 patients), severe acute respiratory syndrome ([SARS] n  =  37), Middle East respiratory syndrome (n  =  2), adenovirus (n  =  34), and respiratory syncytial virus (n  =  30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.
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spelling pubmed-77987212021-01-25 Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases Dolby, Heather W Potey, Philippe Wilder-Smith, Annika B Clohisey, Sara Millar, Jonathan E Baillie, J Kenneth Dorward, David A Lucas, Christopher D Russell, Clark D Open Forum Infect Dis Brief Reports Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n  =  455 patients), severe acute respiratory syndrome ([SARS] n  =  37), Middle East respiratory syndrome (n  =  2), adenovirus (n  =  34), and respiratory syncytial virus (n  =  30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported. Oxford University Press 2020-12-28 /pmc/articles/PMC7798721/ /pubmed/33553478 http://dx.doi.org/10.1093/ofid/ofaa640 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Dolby, Heather W
Potey, Philippe
Wilder-Smith, Annika B
Clohisey, Sara
Millar, Jonathan E
Baillie, J Kenneth
Dorward, David A
Lucas, Christopher D
Russell, Clark D
Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
title Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
title_full Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
title_fullStr Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
title_full_unstemmed Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
title_short Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
title_sort histological evidence of pulmonary microthrombosis and vasculitis in life-threatening respiratory virus diseases
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798721/
https://www.ncbi.nlm.nih.gov/pubmed/33553478
http://dx.doi.org/10.1093/ofid/ofaa640
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