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Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020

BACKGROUND: Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. METHODS: Using data from the Premier Healthcare Database on 181( )813 hospitalized adults diagnosed with COVID-19 during Ma...

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Autores principales: Pennington, Audrey F, Kompaniyets, Lyudmyla, Summers, April D, Danielson, Melissa L, Goodman, Alyson B, Chevinsky, Jennifer R, Preston, Leigh Ellyn, Schieber, Lyna Z, Namulanda, Gonza, Courtney, Joseph, Strosnider, Heather M, Boehmer, Tegan K, Mac Kenzie, William R, Baggs, James, Gundlapalli, Adi V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798738/
https://www.ncbi.nlm.nih.gov/pubmed/33553477
http://dx.doi.org/10.1093/ofid/ofaa638
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author Pennington, Audrey F
Kompaniyets, Lyudmyla
Summers, April D
Danielson, Melissa L
Goodman, Alyson B
Chevinsky, Jennifer R
Preston, Leigh Ellyn
Schieber, Lyna Z
Namulanda, Gonza
Courtney, Joseph
Strosnider, Heather M
Boehmer, Tegan K
Mac Kenzie, William R
Baggs, James
Gundlapalli, Adi V
author_facet Pennington, Audrey F
Kompaniyets, Lyudmyla
Summers, April D
Danielson, Melissa L
Goodman, Alyson B
Chevinsky, Jennifer R
Preston, Leigh Ellyn
Schieber, Lyna Z
Namulanda, Gonza
Courtney, Joseph
Strosnider, Heather M
Boehmer, Tegan K
Mac Kenzie, William R
Baggs, James
Gundlapalli, Adi V
author_sort Pennington, Audrey F
collection PubMed
description BACKGROUND: Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. METHODS: Using data from the Premier Healthcare Database on 181( )813 hospitalized adults diagnosed with COVID-19 during March–September 2020, we applied multivariable log-binomial regression to assess the associations between age and race/ethnicity and COVID-19 clinical severity (intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], and death) and to determine whether the impact of age on clinical severity differs by race/ethnicity. RESULTS: Overall, 84( )497 (47%) patients were admitted to the ICU, 29( )078 (16%) received IMV, and 27( )864 (15%) died in the hospital. Increased age was strongly associated with clinical severity when controlling for underlying medical conditions and other covariates; the strength of this association differed by race/ethnicity. Compared with non-Hispanic White patients, risk of death was lower among non-Hispanic Black patients (adjusted risk ratio, 0.96; 95% CI, 0.92–0.99) and higher among Hispanic/Latino patients (risk ratio [RR], 1.15; 95% CI, 1.09–1.20), non-Hispanic Asian patients (RR, 1.16; 95% CI, 1.09–1.23), and patients of other racial and ethnic groups (RR, 1.13; 95% CI, 1.06–1.21). Risk of ICU admission and risk of IMV were elevated among some racial and ethnic groups. CONCLUSIONS: These results indicate that age is a driver of poor outcomes among hospitalized persons with COVID-19. Additionally, clinical severity may be elevated among patients of some racial and ethnic minority groups. Public health strategies to reduce severe acute respiratory syndrome coronavirus 2 infection rates among older adults and racial and ethnic minorities are essential to reduce poor outcomes.
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spelling pubmed-77987382021-01-25 Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020 Pennington, Audrey F Kompaniyets, Lyudmyla Summers, April D Danielson, Melissa L Goodman, Alyson B Chevinsky, Jennifer R Preston, Leigh Ellyn Schieber, Lyna Z Namulanda, Gonza Courtney, Joseph Strosnider, Heather M Boehmer, Tegan K Mac Kenzie, William R Baggs, James Gundlapalli, Adi V Open Forum Infect Dis Major Articles BACKGROUND: Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. METHODS: Using data from the Premier Healthcare Database on 181( )813 hospitalized adults diagnosed with COVID-19 during March–September 2020, we applied multivariable log-binomial regression to assess the associations between age and race/ethnicity and COVID-19 clinical severity (intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], and death) and to determine whether the impact of age on clinical severity differs by race/ethnicity. RESULTS: Overall, 84( )497 (47%) patients were admitted to the ICU, 29( )078 (16%) received IMV, and 27( )864 (15%) died in the hospital. Increased age was strongly associated with clinical severity when controlling for underlying medical conditions and other covariates; the strength of this association differed by race/ethnicity. Compared with non-Hispanic White patients, risk of death was lower among non-Hispanic Black patients (adjusted risk ratio, 0.96; 95% CI, 0.92–0.99) and higher among Hispanic/Latino patients (risk ratio [RR], 1.15; 95% CI, 1.09–1.20), non-Hispanic Asian patients (RR, 1.16; 95% CI, 1.09–1.23), and patients of other racial and ethnic groups (RR, 1.13; 95% CI, 1.06–1.21). Risk of ICU admission and risk of IMV were elevated among some racial and ethnic groups. CONCLUSIONS: These results indicate that age is a driver of poor outcomes among hospitalized persons with COVID-19. Additionally, clinical severity may be elevated among patients of some racial and ethnic minority groups. Public health strategies to reduce severe acute respiratory syndrome coronavirus 2 infection rates among older adults and racial and ethnic minorities are essential to reduce poor outcomes. Oxford University Press 2020-12-28 /pmc/articles/PMC7798738/ /pubmed/33553477 http://dx.doi.org/10.1093/ofid/ofaa638 Text en Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Major Articles
Pennington, Audrey F
Kompaniyets, Lyudmyla
Summers, April D
Danielson, Melissa L
Goodman, Alyson B
Chevinsky, Jennifer R
Preston, Leigh Ellyn
Schieber, Lyna Z
Namulanda, Gonza
Courtney, Joseph
Strosnider, Heather M
Boehmer, Tegan K
Mac Kenzie, William R
Baggs, James
Gundlapalli, Adi V
Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020
title Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020
title_full Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020
title_fullStr Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020
title_full_unstemmed Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020
title_short Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19—United States, March–September 2020
title_sort risk of clinical severity by age and race/ethnicity among adults hospitalized for covid-19—united states, march–september 2020
topic Major Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798738/
https://www.ncbi.nlm.nih.gov/pubmed/33553477
http://dx.doi.org/10.1093/ofid/ofaa638
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