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Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance

Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive...

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Detalles Bibliográficos
Autores principales: Klumpp-Thomas, Carleen, Kalish, Heather, Hicks, Jennifer, Mehalko, Jennifer, Drew, Matthew, Memoli, Matthew J, Hall, Matthew D, Esposito, Dominic, Sadtler, Kaitlyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798976/
https://www.ncbi.nlm.nih.gov/pubmed/33257936
http://dx.doi.org/10.1093/infdis/jiaa743
Descripción
Sumario:Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.