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Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance

Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive...

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Autores principales: Klumpp-Thomas, Carleen, Kalish, Heather, Hicks, Jennifer, Mehalko, Jennifer, Drew, Matthew, Memoli, Matthew J, Hall, Matthew D, Esposito, Dominic, Sadtler, Kaitlyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798976/
https://www.ncbi.nlm.nih.gov/pubmed/33257936
http://dx.doi.org/10.1093/infdis/jiaa743
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author Klumpp-Thomas, Carleen
Kalish, Heather
Hicks, Jennifer
Mehalko, Jennifer
Drew, Matthew
Memoli, Matthew J
Hall, Matthew D
Esposito, Dominic
Sadtler, Kaitlyn
author_facet Klumpp-Thomas, Carleen
Kalish, Heather
Hicks, Jennifer
Mehalko, Jennifer
Drew, Matthew
Memoli, Matthew J
Hall, Matthew D
Esposito, Dominic
Sadtler, Kaitlyn
author_sort Klumpp-Thomas, Carleen
collection PubMed
description Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.
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spelling pubmed-77989762021-01-25 Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance Klumpp-Thomas, Carleen Kalish, Heather Hicks, Jennifer Mehalko, Jennifer Drew, Matthew Memoli, Matthew J Hall, Matthew D Esposito, Dominic Sadtler, Kaitlyn J Infect Dis Major Articles and Brief Reports Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics. Oxford University Press 2020-12-01 /pmc/articles/PMC7798976/ /pubmed/33257936 http://dx.doi.org/10.1093/infdis/jiaa743 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Major Articles and Brief Reports
Klumpp-Thomas, Carleen
Kalish, Heather
Hicks, Jennifer
Mehalko, Jennifer
Drew, Matthew
Memoli, Matthew J
Hall, Matthew D
Esposito, Dominic
Sadtler, Kaitlyn
Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance
title Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance
title_full Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance
title_fullStr Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance
title_full_unstemmed Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance
title_short Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance
title_sort effect of d614g spike variant on immunoglobulin g, m, or a spike seroassay performance
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798976/
https://www.ncbi.nlm.nih.gov/pubmed/33257936
http://dx.doi.org/10.1093/infdis/jiaa743
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