Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic

Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide...

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Autores principales: Strich, Jeffrey R, Ramos-Benitez, Marcos J, Randazzo, Davide, Stein, Sydney R, Babyak, Ashley, Davey, Richard T, Suffredini, Anthony F, Childs, Richard W, Chertow, Daniel S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799006/
https://www.ncbi.nlm.nih.gov/pubmed/33367731
http://dx.doi.org/10.1093/infdis/jiaa789
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author Strich, Jeffrey R
Ramos-Benitez, Marcos J
Randazzo, Davide
Stein, Sydney R
Babyak, Ashley
Davey, Richard T
Suffredini, Anthony F
Childs, Richard W
Chertow, Daniel S
author_facet Strich, Jeffrey R
Ramos-Benitez, Marcos J
Randazzo, Davide
Stein, Sydney R
Babyak, Ashley
Davey, Richard T
Suffredini, Anthony F
Childs, Richard W
Chertow, Daniel S
author_sort Strich, Jeffrey R
collection PubMed
description Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
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spelling pubmed-77990062021-01-25 Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic Strich, Jeffrey R Ramos-Benitez, Marcos J Randazzo, Davide Stein, Sydney R Babyak, Ashley Davey, Richard T Suffredini, Anthony F Childs, Richard W Chertow, Daniel S J Infect Dis Major Articles and Brief Reports Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis. Oxford University Press 2020-12-24 /pmc/articles/PMC7799006/ /pubmed/33367731 http://dx.doi.org/10.1093/infdis/jiaa789 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Major Articles and Brief Reports
Strich, Jeffrey R
Ramos-Benitez, Marcos J
Randazzo, Davide
Stein, Sydney R
Babyak, Ashley
Davey, Richard T
Suffredini, Anthony F
Childs, Richard W
Chertow, Daniel S
Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
title Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
title_full Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
title_fullStr Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
title_full_unstemmed Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
title_short Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
title_sort fostamatinib inhibits neutrophils extracellular traps induced by covid-19 patient plasma: a potential therapeutic
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799006/
https://www.ncbi.nlm.nih.gov/pubmed/33367731
http://dx.doi.org/10.1093/infdis/jiaa789
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