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Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs

A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of r...

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Autores principales: Shankar, Esaki M, Che, Karlhans F, Yong, Yean K, Girija, A S Smiline, Velu, Vijayakumar, Ansari, Abdul W, Larsson, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799061/
https://www.ncbi.nlm.nih.gov/pubmed/33289808
http://dx.doi.org/10.1093/femspd/ftaa076
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author Shankar, Esaki M
Che, Karlhans F
Yong, Yean K
Girija, A S Smiline
Velu, Vijayakumar
Ansari, Abdul W
Larsson, Marie
author_facet Shankar, Esaki M
Che, Karlhans F
Yong, Yean K
Girija, A S Smiline
Velu, Vijayakumar
Ansari, Abdul W
Larsson, Marie
author_sort Shankar, Esaki M
collection PubMed
description A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of recovery from clinical COVID-19 in certain pockets of the globe is surprisingly high. Based on published reports and available literature, here, we speculated a few immunovirological mechanisms as to why a vast majority of individuals remain asymptomatic similar to exotic animal (bats and pangolins) reservoirs that remain refractile to disease development despite carrying a huge load of diverse insidious viral species, and whether such evolutionary advantage would unveil therapeutic strategies against COVID-19 infection in humans. Understanding the unique mechanisms that exotic animal species employ to achieve viral control, as well as inflammatory regulation, appears to hold key clues to the development of therapeutic versatility against COVID-19.
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spelling pubmed-77990612021-01-25 Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs Shankar, Esaki M Che, Karlhans F Yong, Yean K Girija, A S Smiline Velu, Vijayakumar Ansari, Abdul W Larsson, Marie Pathog Dis Priority Paper A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of recovery from clinical COVID-19 in certain pockets of the globe is surprisingly high. Based on published reports and available literature, here, we speculated a few immunovirological mechanisms as to why a vast majority of individuals remain asymptomatic similar to exotic animal (bats and pangolins) reservoirs that remain refractile to disease development despite carrying a huge load of diverse insidious viral species, and whether such evolutionary advantage would unveil therapeutic strategies against COVID-19 infection in humans. Understanding the unique mechanisms that exotic animal species employ to achieve viral control, as well as inflammatory regulation, appears to hold key clues to the development of therapeutic versatility against COVID-19. Oxford University Press 2020-12-08 /pmc/articles/PMC7799061/ /pubmed/33289808 http://dx.doi.org/10.1093/femspd/ftaa076 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of FEMS. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
spellingShingle Priority Paper
Shankar, Esaki M
Che, Karlhans F
Yong, Yean K
Girija, A S Smiline
Velu, Vijayakumar
Ansari, Abdul W
Larsson, Marie
Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs
title Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs
title_full Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs
title_fullStr Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs
title_full_unstemmed Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs
title_short Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs
title_sort asymptomatic sars-cov-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—clues from exotic animal reservoirs
topic Priority Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799061/
https://www.ncbi.nlm.nih.gov/pubmed/33289808
http://dx.doi.org/10.1093/femspd/ftaa076
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