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Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection

Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reactio...

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Autores principales: Poston, Daniel, Weisblum, Yiska, Wise, Helen, Templeton, Kate, Jenks, Sara, Hatziioannou, Theodora, Bieniasz, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799301/
https://www.ncbi.nlm.nih.gov/pubmed/33270134
http://dx.doi.org/10.1093/cid/ciaa1803
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author Poston, Daniel
Weisblum, Yiska
Wise, Helen
Templeton, Kate
Jenks, Sara
Hatziioannou, Theodora
Bieniasz, Paul
author_facet Poston, Daniel
Weisblum, Yiska
Wise, Helen
Templeton, Kate
Jenks, Sara
Hatziioannou, Theodora
Bieniasz, Paul
author_sort Poston, Daniel
collection PubMed
description Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.
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spelling pubmed-77993012021-01-25 Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection Poston, Daniel Weisblum, Yiska Wise, Helen Templeton, Kate Jenks, Sara Hatziioannou, Theodora Bieniasz, Paul Clin Infect Dis Online Only Articles Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable. Oxford University Press 2020-12-03 /pmc/articles/PMC7799301/ /pubmed/33270134 http://dx.doi.org/10.1093/cid/ciaa1803 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
spellingShingle Online Only Articles
Poston, Daniel
Weisblum, Yiska
Wise, Helen
Templeton, Kate
Jenks, Sara
Hatziioannou, Theodora
Bieniasz, Paul
Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
title Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
title_full Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
title_fullStr Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
title_full_unstemmed Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
title_short Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
title_sort absence of severe acute respiratory syndrome coronavirus 2 neutralizing activity in prepandemic sera from individuals with recent seasonal coronavirus infection
topic Online Only Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799301/
https://www.ncbi.nlm.nih.gov/pubmed/33270134
http://dx.doi.org/10.1093/cid/ciaa1803
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