Cargando…
Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reactio...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799301/ https://www.ncbi.nlm.nih.gov/pubmed/33270134 http://dx.doi.org/10.1093/cid/ciaa1803 |
_version_ | 1783635114163437568 |
---|---|
author | Poston, Daniel Weisblum, Yiska Wise, Helen Templeton, Kate Jenks, Sara Hatziioannou, Theodora Bieniasz, Paul |
author_facet | Poston, Daniel Weisblum, Yiska Wise, Helen Templeton, Kate Jenks, Sara Hatziioannou, Theodora Bieniasz, Paul |
author_sort | Poston, Daniel |
collection | PubMed |
description | Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable. |
format | Online Article Text |
id | pubmed-7799301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77993012021-01-25 Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection Poston, Daniel Weisblum, Yiska Wise, Helen Templeton, Kate Jenks, Sara Hatziioannou, Theodora Bieniasz, Paul Clin Infect Dis Online Only Articles Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable. Oxford University Press 2020-12-03 /pmc/articles/PMC7799301/ /pubmed/33270134 http://dx.doi.org/10.1093/cid/ciaa1803 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
spellingShingle | Online Only Articles Poston, Daniel Weisblum, Yiska Wise, Helen Templeton, Kate Jenks, Sara Hatziioannou, Theodora Bieniasz, Paul Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection |
title | Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection |
title_full | Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection |
title_fullStr | Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection |
title_full_unstemmed | Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection |
title_short | Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection |
title_sort | absence of severe acute respiratory syndrome coronavirus 2 neutralizing activity in prepandemic sera from individuals with recent seasonal coronavirus infection |
topic | Online Only Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799301/ https://www.ncbi.nlm.nih.gov/pubmed/33270134 http://dx.doi.org/10.1093/cid/ciaa1803 |
work_keys_str_mv | AT postondaniel absenceofsevereacuterespiratorysyndromecoronavirus2neutralizingactivityinprepandemicserafromindividualswithrecentseasonalcoronavirusinfection AT weisblumyiska absenceofsevereacuterespiratorysyndromecoronavirus2neutralizingactivityinprepandemicserafromindividualswithrecentseasonalcoronavirusinfection AT wisehelen absenceofsevereacuterespiratorysyndromecoronavirus2neutralizingactivityinprepandemicserafromindividualswithrecentseasonalcoronavirusinfection AT templetonkate absenceofsevereacuterespiratorysyndromecoronavirus2neutralizingactivityinprepandemicserafromindividualswithrecentseasonalcoronavirusinfection AT jenkssara absenceofsevereacuterespiratorysyndromecoronavirus2neutralizingactivityinprepandemicserafromindividualswithrecentseasonalcoronavirusinfection AT hatziioannoutheodora absenceofsevereacuterespiratorysyndromecoronavirus2neutralizingactivityinprepandemicserafromindividualswithrecentseasonalcoronavirusinfection AT bieniaszpaul absenceofsevereacuterespiratorysyndromecoronavirus2neutralizingactivityinprepandemicserafromindividualswithrecentseasonalcoronavirusinfection |