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Population structure of indigenous inhabitants of Arabia
Modern day Saudi Arabia occupies the majority of historical Arabia, which may have contributed to ancient waves of migration out of Africa. This ancient history has left a lasting imprint in the genetics of the region, including the diverse set of tribes that call Saudi Arabia their home. How these...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799765/ https://www.ncbi.nlm.nih.gov/pubmed/33428619 http://dx.doi.org/10.1371/journal.pgen.1009210 |
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author | Mineta, Katsuhiko Goto, Kosuke Gojobori, Takashi Alkuraya, Fowzan S. |
author_facet | Mineta, Katsuhiko Goto, Kosuke Gojobori, Takashi Alkuraya, Fowzan S. |
author_sort | Mineta, Katsuhiko |
collection | PubMed |
description | Modern day Saudi Arabia occupies the majority of historical Arabia, which may have contributed to ancient waves of migration out of Africa. This ancient history has left a lasting imprint in the genetics of the region, including the diverse set of tribes that call Saudi Arabia their home. How these tribes relate to each other and to the world’s major populations remains an unanswered question. In an attempt to improve our understanding of the population structure of Saudi Arabia, we conducted genomic profiling of 957 unrelated individuals who self-identify with 28 large tribes in Saudi Arabia. Consistent with the tradition of intra-tribal unions, the subjects showed strong clustering along tribal lines with the distance between clusters correlating with their geographical proximities in Arabia. However, these individuals form a unique cluster when compared to the world’s major populations. The ancient origin of these tribal affiliations is supported by analyses that revealed little evidence of ancestral origin from within the 28 tribes. Our results disclose a granular map of population structure and have important implications for future genetic studies into Mendelian and common diseases in the region. |
format | Online Article Text |
id | pubmed-7799765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77997652021-01-22 Population structure of indigenous inhabitants of Arabia Mineta, Katsuhiko Goto, Kosuke Gojobori, Takashi Alkuraya, Fowzan S. PLoS Genet Research Article Modern day Saudi Arabia occupies the majority of historical Arabia, which may have contributed to ancient waves of migration out of Africa. This ancient history has left a lasting imprint in the genetics of the region, including the diverse set of tribes that call Saudi Arabia their home. How these tribes relate to each other and to the world’s major populations remains an unanswered question. In an attempt to improve our understanding of the population structure of Saudi Arabia, we conducted genomic profiling of 957 unrelated individuals who self-identify with 28 large tribes in Saudi Arabia. Consistent with the tradition of intra-tribal unions, the subjects showed strong clustering along tribal lines with the distance between clusters correlating with their geographical proximities in Arabia. However, these individuals form a unique cluster when compared to the world’s major populations. The ancient origin of these tribal affiliations is supported by analyses that revealed little evidence of ancestral origin from within the 28 tribes. Our results disclose a granular map of population structure and have important implications for future genetic studies into Mendelian and common diseases in the region. Public Library of Science 2021-01-11 /pmc/articles/PMC7799765/ /pubmed/33428619 http://dx.doi.org/10.1371/journal.pgen.1009210 Text en © 2021 Mineta et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mineta, Katsuhiko Goto, Kosuke Gojobori, Takashi Alkuraya, Fowzan S. Population structure of indigenous inhabitants of Arabia |
title | Population structure of indigenous inhabitants of Arabia |
title_full | Population structure of indigenous inhabitants of Arabia |
title_fullStr | Population structure of indigenous inhabitants of Arabia |
title_full_unstemmed | Population structure of indigenous inhabitants of Arabia |
title_short | Population structure of indigenous inhabitants of Arabia |
title_sort | population structure of indigenous inhabitants of arabia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799765/ https://www.ncbi.nlm.nih.gov/pubmed/33428619 http://dx.doi.org/10.1371/journal.pgen.1009210 |
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