Sequence analysis of the ATP synthase of subunits (ATP8 and ATP6) genes of mitochondrial DNA genome from Ailuropoda melanoleuca

To explore the effects of the mutations of ATP6 and ATP8 genes on energy metabolism and genetic structure, we sequenced the ATP6 and ATP8 genes of Ailuropoda melanoleuca. Our results showed that ATP8 is a conserved gene and ATP6 gene is positively selected during the evolution of the giant panda pop...

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Detalles Bibliográficos
Autores principales: Hu, Yaodong, Pang, Huizhong, Ling, Shanshan, Wei, Rongping, Zhu, Yun, Zhang, Hemin, Li, Diyan, Li, Desheng, Wang, Chengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
MITO Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800081/
https://www.ncbi.nlm.nih.gov/pubmed/33474428
http://dx.doi.org/10.1080/23802359.2018.1424574
Descripción
Sumario:To explore the effects of the mutations of ATP6 and ATP8 genes on energy metabolism and genetic structure, we sequenced the ATP6 and ATP8 genes of Ailuropoda melanoleuca. Our results showed that ATP8 is a conserved gene and ATP6 gene is positively selected during the evolution of the giant panda population with a low genetic diversity. Population expansion was observed in the giant panda group. The T179C mutation on Haplotype7 made the production of a potential phosphorylation site. This non-synonymous mutation may occur at the post-translational modification site that have a potential effect on the function of ATP synthase, related to the maintenance of body temperature of pandas at low metabolic rates.

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