Cargando…

Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of ‘cancer stem cells (CSCs)’ in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maruno, Takahisa, Fukuda, Akihisa, Goto, Norihiro, Tsuda, Motoyuki, Ikuta, Kozo, Hiramatsu, Yukiko, Ogawa, Satoshi, Nakanishi, Yuki, Yamaga, Yuichi, Yoshioka, Takuto, Takaori, Kyoichi, Uemoto, Shinji, Saur, Dieter, Chiba, Tsutomu, Seno, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7800378/ https://www.ncbi.nlm.nih.gov/pubmed/33393460 http://dx.doi.org/10.7554/eLife.55117

Ejemplares similares

JNK pathway plays a critical role for expansion of human colorectal cancer in the context of BRG1 suppression
por: Yoshikawa, Takaaki, et al.
Publicado: (2022)

Epithelial EP4 plays an essential role in maintaining homeostasis in colon
por: Matsumoto, Yoshihide, et al.
Publicado: (2019)

p53 protects against formation of extrahepatic biliary precancerous lesions in the context of oncogenic Kras
por: Nagao, Munemasa, et al.
Publicado: (2023)

Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis
por: Masuda, Tomonori, et al.
Publicado: (2023)

Deletion of Nardilysin Prevents the Development of Steatohepatitis and Liver Fibrotic Changes
por: Ishizu-Higashi, Shoko, et al.
Publicado: (2014)

The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma
por: Tsuda, Motoyuki, et al.
Publicado: (2020)

Neutrophil-to-lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients
por: Xue, Peng, et al.
Publicado: (2014)

Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach
por: Kimura, Yuto, et al.
Publicado: (2017)

Self-expandable metallic stent placement for malignant biliary stricture using a novel device delivery system
por: Matsumori, Tomoaki, et al.
Publicado: (2021)

Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment
por: Ikuta, Kozo, et al.
Publicado: (2019)

SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2
por: Masuo, Kenji, et al.
Publicado: (2021)

Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice
por: Sakuma, Yojiro, et al.
Publicado: (2018)

Usefulness of a circumferential argon plasma coagulation probe in trimming a dislocated distal biliary metal stent
por: Yokode, Masataka, et al.
Publicado: (2022)

Additional stenting for hilar cholangiocarcinoma using a novel delivery device after uncovered metallic stent placements
por: Yasuda, Muneji, et al.
Publicado: (2023)

The role of Kras and canonical Wnt pathways for tumorigenesis of extrahepatic biliary system
por: Nagao, Munemasa, et al.
Publicado: (2023)

A case of successful conversion from everolimus to surgical resection of a giant pancreatic neuroendocrine tumor
por: Sato, Asahi, et al.
Publicado: (2017)

EP4 Receptor–Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis
por: Nakatsuji, Masato, et al.
Publicado: (2015)

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer
por: Omatsu, Mayuki, et al.
Publicado: (2023)

Gastric Cancer from a Hyperplastic Polyp on an Endoscopic Submucosal Dissection Scar
por: Sono, Makoto, et al.
Publicado: (2018)

Paraplegia as an initial manifestation of pancreatic cancer
por: Sono, Makoto, et al.
Publicado: (2019)

Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice
por: Fukuda, Akihisa, et al.
Publicado: (2008)

A New Index for the Quantitative Evaluation of Surgical Invasiveness Based on Perioperative Patients’ Behavior Patterns: Machine Learning Approach Using Triaxial Acceleration
por: Nakanishi, Kozo, et al.
Publicado: (2023)

Pulmonary actinomycosis mimicking a lung metastasis from esophageal cancer; a case report
por: Nagao, Munemasa, et al.
Publicado: (2018)

A Rare Case of Lymph Node Metastasis from Early Gastric Cancer
por: Yoshikawa, Takaaki, et al.
Publicado: (2019)

Laparoscopic Distal Pancreatectomy with or without Preservation of the Spleen for Solid Pseudopapillary Neoplasm
por: Hori, Tomohide, et al.
Publicado: (2015)

Mitomycin C treatment improves pancreatic islet graft longevity in intraportal islet transplantation by suppressing proinflammatory response
por: Yamane, Kei, et al.
Publicado: (2020)

The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation
por: Tada, Seiichiro, et al.
Publicado: (2020)

Autoimmune Pancreatitis Exhibiting Multiple Mass Lesions
por: Shiokawa, Masahiro, et al.
Publicado: (2011)

Changes in Psychosocial Conditions and Eventual Mortality in Community-residing Elderly People
por: Nakanishi, Noriyuki, et al.
Publicado: (2007)

Familial Pancreatic Cancer and Surveillance of High-Risk Individuals
por: Matsubayashi, Hiroyuki, et al.
Publicado: (2019)

A case of napsin A-positive metastatic lung cancer originating from the colon
por: Ito, Tomokazu, et al.
Publicado: (2017)

Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer
por: Kawada, Mayumi, et al.
Publicado: (2011)

Impact of neoadjuvant intensity-modulated radiation therapy on borderline resectable pancreatic cancer with arterial abutment; a prospective, open-label, phase II study in a single institution
por: Masui, Toshihiko, et al.
Publicado: (2022)

Effect of Instrumental Activities of Daily Living habituation due to routinising therapy in patients with frontotemporal dementia
por: Nakanishi, Kosuke, et al.
Publicado: (2021)

Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice
por: Watanabe, Norihiko, et al.
Publicado: (2002)

Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α
por: Kanda, Keitaro, et al.
Publicado: (2012)

Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing
por: Nishijima, Norihiro, et al.
Publicado: (2012)

Mixed acinar-neuroendocrine carcinoma of the pancreas with positive for microsatellite instability: a case report and review of the literature
por: Yoshino, Kenji, et al.
Publicado: (2023)

Pancreatic metastasis from lung adenocarcinoma
por: Aoyama, Naoki, et al.
Publicado: (2023)

Should Lung-Sparing Surgery Be the Standard Procedure for Malignant Pleural Mesothelioma?
por: Ichiki, Yoshinobu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6k5en1da0c1aqaordph0e3m0dm